Traits

Traits linked to MALT1

MALT1 paracaspase

The Human Phenotype Ontology links 36 traits to MALT1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Absent circulating isohemagglutinin	Always
Complete or near-complete absence of specific antibody response to tetanus vaccine	Always
Decreased immune function	Always
Recurrent bacterial infections	Always
Recurrent chest infections	Always
Recurrent viral infections	Always
Skin rash	Always
Recurrent respiratory infections	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Inflammation of the lips	Always
Mastoiditis	Always
Recurrent canker sores	Always
Abnormal nasolacrimal system morphology	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Narrowing of esophagus due to inflammation and scar tissue	Always
Nausea and vomiting	Very often (80–99%)
Constipation	Often (30–79%)
Abdominal pain	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Decreased body weight	Always
Growth delay	Always
Short stature	Always
Weight loss	Very often (80–99%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
B-cell lymphoma	Very often (80–99%)
Low number of red blood cells or hemoglobin	Very often (80–99%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Swollen lymph nodes	Sometimes (5–29%)
Swollen lymph nodes in center of chest	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Posterior uveitis	Sometimes (5–29%)
Visual impairment	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Delayed bone maturation	Always
Osteoporosis	Always

Abnormality of the respiratory system

Trait	How often it is seen
Permanent enlargement of the airways of the lungs	Always
Lung infiltrates	Very often (80–99%)

Abnormal cellular phenotype

Trait	How often it is seen
Decreased anti-CD3/28-induced T-cell proliferation	Always

Abnormality of limbs

Trait	How often it is seen
Clubbing of fingers and toes	Always

Abnormality of the endocrine system

Trait	How often it is seen
Abnormality of the thyroid gland	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Excessive sweating	Very often (80–99%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)

Laboratory abnormality

Trait	How often it is seen
Fever	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MALT1 and how often each is seen. Find out more at hpo.jax.org.

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