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Gene

TOP6BL

TOP6B like initiator of meiotic double strand breaks

Summary

Cytogenetic location
11q13.2
Coordinates
Chromosome 11: 66,744,769–66,843,516 (GRCh38)
Exons
15 exons across 98.7 kb
Protein
511 amino acids
Also known as
FLJ22531, TOPOVIBL
Previous symbols
C11orf80
MANE Select transcript
ENST00000540737.7NM_001302084.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TOP6BL yet. The test sequences your whole genome, so your data includes it all the same.

How TOP6BL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where TOP6BL sits. TOP6BL and 31 genes near it on chromosome 11, from 66,294,143 to 67,294,142.Chromosome 1111q13.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2566.4 Mb66.6 Mb66.8 Mb67 Mb67.2 MbTMEM151A: 66,291,832–66,299,036, forward strandCD248: 66,314,494–66,317,044, reverse strandRIN1: 66,330,241–66,336,840, reverse strandRIN1BRMS1: 66,337,332–66,345,136, reverse strandBRMS1B4GAT1: 66,345,374–66,347,856, reverse strandB4GAT1SLC29A2: 66,360,101–66,372,476, reverse strandSLC29A2NPAS4: 66,421,033–66,426,707, forward strandNPAS4MRPL11: 66,435,075–66,466,738, reverse strandMRPL11PELI3: 66,466,303–66,478,998, forward strandPELI3DPP3: 66,479,990–66,510,188, forward strandDPP3: 66,509,079–66,533,613, forward strandBBS1: 66,510,606–66,534,660, forward strandBBS1ZDHHC24: 66,520,620–66,546,244, reverse strandZDHHC24ACTN3: 66,546,395–66,563,334, forward strandACTN3CTSF: 66,563,462–66,568,879, reverse strandCTSFCCDC87: 66,590,176–66,593,063, reverse strandCCDC87CCS: 66,592,843–66,606,703, forward strandCCSRBM14: 66,616,594–66,629,934, forward strandRBM14RBM14-RBM4: 66,616,626–66,646,469, forward strandRBM14-RBM4RBM4: 66,637,771–66,668,380, forward strandRBM4RBM4B: 66,664,994–66,677,925, reverse strandRBM4BSPTBN2: 66,682,496–66,744,670, reverse strandSPTBN2TOP6BL: 66,744,769–66,843,516, forward strandTOP6BLRCE1: 66,842,835–66,848,159, forward strandRCE1PC: 66,848,208–66,958,524, reverse strandPCLRFN4: 66,856,546–66,860,475, forward strandLRFN4C11orf86: 66,975,272–66,977,009, forward strandC11orf86SYT12: 67,006,772–67,051,110, forward strandSYT12RHOD: 67,056,608–67,072,044, forward strandRHODKDM2A: 67,119,247–67,258,082, forward strandKDM2AGRK2: 67,266,351–67,286,562, forward strandGRK2ANKRD13D: 67,288,655–67,302,486, forward strandANKRD13DDiagram of TOP6BL: 15 exons on the forward strand of chromosome 11Exon 14: 1 known disease-causing siteExon 1: 66,744,769–66,744,919, 151 basesExon 2: 66,759,043–66,759,096, 54 basesExon 3: 66,788,160–66,788,269, 110 basesExon 4: 66,796,281–66,796,364, 84 basesExon 5: 66,800,641–66,800,696, 56 basesExon 6: 66,801,031–66,801,102, 72 basesExon 7: 66,803,995–66,804,190, 196 basesExon 8: 66,813,865–66,814,015, 151 basesExon 9: 66,816,053–66,816,199, 147 basesExon 10: 66,821,643–66,821,764, 122 basesExon 11: 66,822,564–66,822,674, 111 basesExon 12: 66,828,266–66,828,364, 99 basesExon 13: 66,838,370–66,838,445, 76 basesExon 14: 66,842,849–66,843,069, 221 basesExon 15: 66,843,169–66,843,516, 348 bases1510155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 98.7 kb; 1,536 of those bases code for the protein.

How a genome test reads TOP6BL

1

position in TOP6BL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 98.7 kb of TOP6BL, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TOP6BL gene: TOP6B like initiator of meiotic double strand breaks. Retrieved 16 October 2026, from https://dantelabs.com/genes/top6bl

Vancouver

Dante Labs. TOP6BL gene: TOP6B like initiator of meiotic double strand breaks [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/top6bl

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