Trait

Cleft in skull base

A bony defect in the skull base.

HPO HP:0009752

Also called: Cleft in cranial base
Body system: Abnormality of head or neck Abnormality of the musculoskeletal system

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1 gene linked to Cleft in skull base

Changes in these genes cause rare conditions in which Cleft in skull base is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
HYLS1HYLS1 centriolar and ciliogenesis associated	Often (30–79%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the skull base

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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