Traits

Traits linked to FOSL2

FOS like 2, AP-1 transcription factor subunit

The Human Phenotype Ontology links 19 traits to FOSL2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Focal absence of scalp tissue	Very often (80–99%)
Brittle nails	Sometimes (5–29%)
Dry skin	Sometimes (5–29%)
Excessive hair growth	Sometimes (5–29%)
Small nail	Sometimes (5–29%)
Sparse hair	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Autism spectrum disorder	Often (30–79%)
Global developmental delay	Often (30–79%)
Cerebellar vermis hypoplasia	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Short corpus callosum	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Thin dental enamel	Always
Delayed eruption of teeth	Sometimes (5–29%)
Early tooth loss	Sometimes (5–29%)
Failure of development of between one and six teeth	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Growth delay as children	Often (30–79%)
Prenatal growth deficiency	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Cutis marmorata	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Clouding of the lens of the eye	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FOSL2 and how often each is seen. Find out more at hpo.jax.org.

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