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Gene

FHOD3

formin homology 2 domain containing 3

Summary

Cytogenetic location
18q12.2
Coordinates
Chromosome 18: 36,297,713–36,780,220 (GRCh38)
Exons
29 exons across 482.5 kb
Protein
1,622 amino acids
Inheritance
Autosomal dominant
Also known as
FHOS2, KIAA1695, FLJ22297, FLJ22717
MANE Select transcript
ENST00000590592.6NM_001281740.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hypertrophic Cardiomyopathy

      • Autosomal dominant

        One of 62 genes linked to it

        A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong
        What knowing changes

        Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

    Inheritance

    Autosomal dominant
    One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

    How FHOD3 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 18, with a bracket where FHOD3 sits. FHOD3 and 8 genes near it on chromosome 18, from 35,815,205 to 37,262,728.Chromosome 1818q12.2p11.32p11.31p11.23p11.22p11.21p11.1q11.1q11.2q12.1q12.2q12.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q2336 Mb36.2 Mb36.4 Mb36.6 Mb36.8 Mb37 Mb37.2 MbRMP24: 35,972,600–36,010,346, forward strandRMP24RPRD1A: 35,982,919–36,067,651, reverse strandRPRD1ASLC39A6: 36,108,531–36,129,827, reverse strandSLC39A6ELP2: 36,129,444–36,180,557, forward strandELP2MOCOS: 36,186,894–36,272,157, forward strandMOCOSFHOD3: 36,297,713–36,780,220, forward strandFHOD3TPGS2: 36,777,647–36,829,216, reverse strandTPGS2KIAA1328: 36,828,952–37,232,172, forward strandKIAA1328CELF4: 37,243,040–37,565,994, reverse strandCELF4Diagram of FHOD3: 29 exons on the forward strand of chromosome 18Exon 12: 2 known disease-causing sitesExon 1: 36,297,713–36,298,000, 288 basesExon 2: 36,355,539–36,355,645, 107 basesExon 3: 36,372,680–36,372,744, 65 basesExon 4: 36,501,932–36,501,999, 68 basesExon 5: 36,512,438–36,512,543, 106 basesExon 6: 36,576,451–36,576,545, 95 basesExon 7: 36,594,787–36,594,898, 112 basesExon 8: 36,602,674–36,602,768, 95 basesExon 9: 36,611,952–36,612,095, 144 basesExon 10: 36,625,511–36,625,749, 239 basesExon 11: 36,649,316–36,649,405, 90 basesExon 12: 36,652,570–36,652,929, 360 basesExon 13: 36,653,342–36,653,416, 75 basesExon 14: 36,658,075–36,658,188, 114 basesExon 15: 36,681,436–36,681,570, 135 basesExon 16: 36,687,128–36,687,178, 51 basesExon 17: 36,693,209–36,693,423, 215 basesExon 18: 36,709,095–36,709,391, 297 basesExon 19: 36,717,832–36,718,715, 884 basesExon 20: 36,730,646–36,730,804, 159 basesExon 21: 36,740,656–36,740,838, 183 basesExon 22: 36,742,737–36,742,856, 120 basesExon 23: 36,744,032–36,744,193, 162 basesExon 24: 36,746,945–36,747,135, 191 basesExon 25: 36,755,119–36,755,311, 193 basesExon 26: 36,759,118–36,759,141, 24 basesExon 27: 36,760,608–36,760,782, 175 basesExon 28: 36,769,265–36,769,426, 162 basesExon 29: 36,779,448–36,780,220, 773 bases1510152025295′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.7 kb of the gene's 482.5 kb; 4,869 of those bases code for the protein.

    How a genome test reads FHOD3

    3

    positions in FHOD3 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 482.5 kb of FHOD3, introns included, not only the 5.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). FHOD3 gene: formin homology 2 domain containing 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/fhod3

    Vancouver

    Dante Labs. FHOD3 gene: formin homology 2 domain containing 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fhod3

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