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Gene

CRLS1

cardiolipin synthase 1

Summary

Cytogenetic location
20p12.3
Coordinates
Chromosome 20: 6,006,123–6,040,053 (GRCh38)
Exons
7 exons across 33.9 kb
Protein
301 amino acids
Also known as
dJ967N21.6, CLS1, GCD10
Previous symbols
C20orf155
MANE Select transcript
ENST00000378863.9NM_019095.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Mitochondrial Disease

    • Combined Oxidative Phosphorylation Deficiency

      Disorders, usually caused by nuclear genes involved in mitochondrial protein production, that reduce several respiratory chain complexes at once and often cause severe multisystem disease in childhood.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing can end a diagnostic search and guide surveillance and supportive care.

How CRLS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 20, with a bracket where CRLS1 sits. CRLS1 and 8 genes near it on chromosome 20, from 5,523,088 to 6,523,087.Chromosome 2020p12.3p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.335.6 Mb5.8 Mb6 Mb6.2 Mb6.4 MbGPCPD1: 5,544,404–5,611,058, reverse strandGPCPD1SHLD1: 5,750,334–5,865,795, forward strandSHLD1CHGB: 5,911,389–5,925,940, forward strandCHGBTRMT6: 5,936,920–5,950,566, reverse strandTRMT6MCM8: 5,949,767–5,998,977, forward strandMCM8: 5,950,949–6,039,856, forward strandCRLS1: 6,006,123–6,040,053, forward strandCRLS1LRRN4: 6,036,480–6,060,313, reverse strandLRRN4FERMT1: 6,070,288–6,123,644, reverse strandFERMT1Diagram of CRLS1: 7 exons on the forward strand of chromosome 20Exon 1: 6,006,123–6,006,552, 430 basesExon 2: 6,009,775–6,009,912, 138 basesExon 3: 6,015,361–6,015,490, 130 basesExon 4: 6,031,285–6,031,370, 86 basesExon 5: 6,032,012–6,032,080, 69 basesExon 6: 6,034,464–6,034,555, 92 basesExon 7: 6,037,074–6,040,053, 2,980 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 33.9 kb; 906 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CRLS1 gene: cardiolipin synthase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/crls1

Vancouver

Dante Labs. CRLS1 gene: cardiolipin synthase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/crls1

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