Traits

Traits linked to ARHGAP29

Rho GTPase activating protein 29

The Human Phenotype Ontology links 21 traits to ARHGAP29, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Abnormality of tooth eruption	Very often (80–99%)
Cleft of the mouth	Often (30–79%)
Cleft palate	Often (30–79%)
One sided cleft palate	Often (30–79%)
Velopharyngeal incompetence	Often (30–79%)
Abnormal number of permanent teeth	Sometimes (5–29%)
Bad bite	Sometimes (5–29%)
Hole in roof of mouth	Sometimes (5–29%)
Missing lateral incisor	Sometimes (5–29%)
Peg-shaped maxillary lateral incisors	Sometimes (5–29%)
Right and left cleft palate	Sometimes (5–29%)
Decreased size of maxilla	Rarely (1–4%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties in infancy	Often (30–79%)
Oral-pharyngeal dysphagia	Often (30–79%)
Poor suck	Often (30–79%)
Malnutrition	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Often (30–79%)
Conductive deafness	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Often (30–79%)
Speech articulation difficulties	Often (30–79%)

Abnormality of the voice

Trait	How often it is seen
Nasal speech	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ARHGAP29 and how often each is seen. Find out more at hpo.jax.org.

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