{
  "url": "https://dantelabs.com/traits/rheumatoid-factor-positive",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "rheumatoid-factor-positive",
    "id": "HP:0002923",
    "name": "Rheumatoid factor positive",
    "definition": "The presence in the serum of an autoantibody directed against the Fc portion of IgG.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "autoimmune-antibody-positivity",
        "name": "Autoimmune antibody positivity",
        "url": "https://dantelabs.com/traits/autoimmune-antibody-positivity"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "lyn",
        "symbol": "LYN",
        "hgnc": "HGNC:6735",
        "name": "LYN proto-oncogene, Src family tyrosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyn"
      },
      {
        "slug": "sting1",
        "symbol": "STING1",
        "hgnc": "HGNC:27962",
        "name": "stimulator of interferon response cGAMP interactor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sting1"
      },
      {
        "slug": "pgm3",
        "symbol": "PGM3",
        "hgnc": "HGNC:8907",
        "name": "phosphoglucomutase 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pgm3"
      },
      {
        "slug": "c1qb",
        "symbol": "C1QB",
        "hgnc": "HGNC:1242",
        "name": "complement C1q B chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1qb"
      },
      {
        "slug": "card10",
        "symbol": "CARD10",
        "hgnc": "HGNC:16422",
        "name": "caspase recruitment domain family member 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card10"
      },
      {
        "slug": "dock11",
        "symbol": "DOCK11",
        "hgnc": "HGNC:23483",
        "name": "dedicator of cytokinesis 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock11"
      },
      {
        "slug": "cybc1",
        "symbol": "CYBC1",
        "hgnc": "HGNC:28672",
        "name": "cytochrome b-245 chaperone 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybc1"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "ripk1",
        "symbol": "RIPK1",
        "hgnc": "HGNC:10019",
        "name": "receptor interacting serine/threonine kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ripk1"
      },
      {
        "slug": "ccn6",
        "symbol": "CCN6",
        "hgnc": "HGNC:12771",
        "name": "cellular communication network factor 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccn6"
      },
      {
        "slug": "cd244",
        "symbol": "CD244",
        "hgnc": "HGNC:18171",
        "name": "CD244 molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd244"
      },
      {
        "slug": "ciita",
        "symbol": "CIITA",
        "hgnc": "HGNC:7067",
        "name": "class II major histocompatibility complex transactivator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciita"
      },
      {
        "slug": "ifngr1",
        "symbol": "IFNGR1",
        "hgnc": "HGNC:5439",
        "name": "interferon gamma receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifngr1"
      },
      {
        "slug": "il10",
        "symbol": "IL10",
        "hgnc": "HGNC:5962",
        "name": "interleukin 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10"
      },
      {
        "slug": "nfkbil1",
        "symbol": "NFKBIL1",
        "hgnc": "HGNC:7800",
        "name": "NFKB inhibitor like 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfkbil1"
      },
      {
        "slug": "slc22a4",
        "symbol": "SLC22A4",
        "hgnc": "HGNC:10968",
        "name": "solute carrier family 22 member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc22a4"
      }
    ]
  }
}