Traits

Traits linked to UMOD

uromodulin

The Human Phenotype Ontology links 31 traits to UMOD, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Chronic kidney disease	Always
Renal failure	Always
Renal tubular atrophy	Always
Stage 2 chronic kidney disease	Always
Stage 3 chronic kidney disease	Always
Stage 4 chronic kidney disease	Always
Tubulointerstitial nephritis	Always
Decreased glomerular filtration rate	Very often (80–99%)
Renal interstitial fibrosis	Very often (80–99%)
Cystic kidney disease	Often (30–79%)
Glomerular sclerosis	Often (30–79%)
Increased urine output	Often (30–79%)
Renal corticomedullary cysts	Often (30–79%)
Small kidneys	Often (30–79%)
Stage 1 chronic kidney disease	Often (30–79%)
Stage 5 chronic kidney disease	Often (30–79%)
Thickened glomerular basement membrane	Often (30–79%)
Hyperechogenic kidneys	Sometimes (5–29%)
Reduced renal corticomedullary differentiation	Sometimes (5–29%)
Kidney inflammation	Not recorded

Laboratory abnormality

Trait	How often it is seen
Decreased urinary urate	Always
Elevated circulating parathyroid hormone level	Always
Increased blood urea nitrogen	Always
Metabolic acidosis	Always
Elevated creatinine	Very often (80–99%)
High blood uric acid level	Often (30–79%)
High urine protein levels	Often (30–79%)
Hyposthenuria	Often (30–79%)
Blood in urine	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Gout	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to UMOD and how often each is seen. Find out more at hpo.jax.org.

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