Traits

Traits linked to TOM1

target of myb1 membrane trafficking protein

The Human Phenotype Ontology links 21 traits to TOM1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Reduced total natural killer cell count	Always
Decreased blood lymphocyte number	Often (30–79%)
Decreased total CD4+ T cell proportion	Often (30–79%)
Low T cell count	Often (30–79%)
Decreased memory B cell proportion	Not recorded

Abnormal cellular phenotype

Trait	How often it is seen
Decreased circulating IgA concentration	Always
Decreased circulating IgG concentration	Always
Decreased circulating IgM concentration	Always
Decreased circulating IgE concentration	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Chronic diarrhea	Always
Vomiting	Always
Tube feeding	Often (30–79%)
Villous atrophy	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Eczema	Always
Recurrent respiratory infections	Always
Red scaly skin caused by inflammatory skin disease	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Growth delay	Always
Faltering weight in infancy	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Oligoarthritis	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Pulmonary scarring	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Persistent EBV viremia	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TOM1 and how often each is seen. Find out more at hpo.jax.org.

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