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Trait

Decreased circulating IgE concentration

An abnormally decreased level of immunoglobulin E (IgE) in blood.

HPO HP:0005479

Summary

Also called
Decreased circulating IgE, Decreased IgE, IgE deficiency
Body system
Abnormal cellular phenotypeAbnormality of blood and blood-forming tissuesLaboratory abnormalityAbnormality of the immune system

11 genes linked to Decreased circulating IgE concentration

Changes in these genes cause rare conditions in which Decreased circulating IgE concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
BTKBruton tyrosine kinaseAlwaysIn 1 condition
IRF4interferon regulatory factor 4AlwaysIn 1 condition
LCKLCK proto-oncogene, Src family tyrosine kinaseAlwaysIn 1 condition
NBNnibrinAlwaysIn 1 condition
TCF3transcription factor 3AlwaysIn 1 condition
WASWASP actin nucleation promoting factorAlwaysIn 1 condition
BACH2BACH transcriptional regulator 2Often (30–79%)In 1 condition
TOM1target of myb1 membrane trafficking proteinOften (30–79%)In 1 condition
CD40CD40 moleculeNot recordedIn 1 condition
CD40LGCD40 ligandNot recordedIn 1 condition
IL2RGinterleukin 2 receptor subunit gammaNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal circulating IgE concentrationDecreased circulating antibody level

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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