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Gene

CDC14A

cell division cycle 14A

Summary

Cytogenetic location
1p21.2
Coordinates
Chromosome 1: 100,352,506–100,520,277 (GRCh38)
Exons
16 exons across 167.8 kb
Protein
594 amino acids
Also known as
Cdc14A1, Cdc14A2, cdc14, DFNB105
Previous symbols
DFNB32
MANE Select transcript
ENST00000336454.5NM_003672.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Male Infertility

    • Hearing impairment and infertile male syndrome (CDC14A)Autosomal recessive

      A recessive condition caused by biallelic CDC14A variants that causes hearing loss and, in men, infertility.

      • ClinGen rates the link strong
      • 1 GenCC submitter rates it definitive or strong

Broader groupings

  • Hearing Loss and Deafness

    • Nonsyndromic Genetic Hearing Loss

      One of 97 genes linked to it

      Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      Actionability

      Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

How CDC14A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where CDC14A sits. CDC14A and 13 genes near it on chromosome 1, from 99,936,392 to 100,936,391.Chromosome 11p21.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44100 Mb100.2 Mb100.4 Mb100.6 Mb100.8 MbSLC35A3: 99,969,351–100,035,634, forward strandSLC35A3: 99,970,011–100,083,321, forward strandSLC71A1: 100,038,076–100,083,948, forward strandSLC71A1SASS6: 100,083,563–100,132,955, reverse strandSASS6TRMT13: 100,133,043–100,151,150, forward strandTRMT13LRRC39: 100,146,522–100,178,306, reverse strandLRRC39DBT: 100,182,222–100,249,873, reverse strandDBTRTCA: 100,266,154–100,292,769, forward strandRTCACDC14A: 100,352,506–100,520,277, forward strandCDC14AGPR88: 100,538,105–100,542,021, forward strandGPR88VCAM1: 100,719,684–100,739,045, forward strandVCAM1EXTL2: 100,871,371–100,896,000, reverse strandEXTL2SLC30A7: 100,896,061–100,996,627, forward strandSLC30A7DPH5: 100,926,286–101,026,117, reverse strandDPH5Diagram of CDC14A: 16 exons on the forward strand of chromosome 1Exon 6: 1 known disease-causing siteExon 10: 3 known disease-causing sitesExon 11: 3 known disease-causing sitesExon 14: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 1: 100,352,506–100,353,003, 498 basesExon 2: 100,353,762–100,353,852, 91 basesExon 3: 100,377,546–100,377,621, 76 basesExon 4: 100,390,732–100,390,824, 93 basesExon 5: 100,424,222–100,424,301, 80 basesExon 6: 100,439,932–100,439,998, 67 basesExon 7: 100,442,934–100,442,996, 63 basesExon 8: 100,455,405–100,455,492, 88 basesExon 9: 100,462,651–100,462,881, 231 basesExon 10: 100,467,956–100,468,094, 139 basesExon 11: 100,484,292–100,484,451, 160 basesExon 12: 100,494,818–100,494,930, 113 basesExon 13: 100,496,002–100,496,049, 48 basesExon 14: 100,498,085–100,498,207, 123 basesExon 15: 100,498,929–100,499,262, 334 basesExon 16: 100,518,251–100,520,277, 2,027 bases151015165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 167.8 kb; 1,785 of those bases code for the protein.

Sequencing CDC14A

10

positions in CDC14A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 167.8 kb of CDC14A, introns included, not only the 4.2 kb of exons.

Genes linked to the same conditions

Traits linked to CDC14A

The Human Phenotype Ontology lists these as features of the rare conditions CDC14A can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CDC14A gene: cell division cycle 14A. Retrieved 17 October 2026, from https://dantelabs.com/genes/cdc14a

Vancouver

Dante Labs. CDC14A gene: cell division cycle 14A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cdc14a

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