Traits

Traits linked to SIN3B

SIN3 transcription regulator family member B

The Human Phenotype Ontology links 20 traits to SIN3B, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Brain imaging abnormality	Very often (80–99%)
Intellectual disability, mild	Very often (80–99%)
Autism spectrum disorder	Often (30–79%)
Mild malformation of cortical development	Often (30–79%)
Ventriculomegaly	Often (30–79%)
Abnormal cerebral white matter morphology	Sometimes (5–29%)
Dysplastic corpus callosum	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Obsessive compulsive behavior	Sometimes (5–29%)
Short attention span	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormal facial shape	Very often (80–99%)
Decreased head circumference	Often (30–79%)
Abnormal dentition	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormality of the skeletal system	Often (30–79%)
Double-Jointed	Often (30–79%)
Delayed bone maturation	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Brittle nails	Sometimes (5–29%)
Fine hair	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of digit	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SIN3B and how often each is seen. Find out more at hpo.jax.org.

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