Traits

Traits linked to RRAGC

Ras related GTP binding C

The Human Phenotype Ontology links 27 traits to RRAGC, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Cardiac failure	Always
Enlarged heart	Always
Severely reduced left ventricular ejection fraction	Always
Stretched and thinned heart muscle	Always
Hole in heart wall separating two lower heart chambers	Often (30–79%)
Secundum atrial septal defect	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating alanine aminotransferase concentration	Always
Elevated circulating aspartate aminotransferase concentration	Always
Higher than normal levels of lactate in blood	Always
Low blood sugar	Always
High blood ammonia levels	Often (30–79%)
Nonimmune hydrops fetalis	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Clouding of the lens of the eye	Often (30–79%)
Microspherophakia	Often (30–79%)
Optic nerve hypoplasia	Often (30–79%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Cavum septum pellucidum	Often (30–79%)
Fewer and broader ridges in brain	Often (30–79%)
More grooves in brain	Often (30–79%)
Subependymal cysts	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Big calvaria	Always
Downward slanting of the opening between the eyelids	Always
Prominent forehead	Always

Abnormality of prenatal development or birth

Trait	How often it is seen
Premature rupture of membranes	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RRAGC and how often each is seen. Find out more at hpo.jax.org.

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