Traits

Traits linked to RASGRP1

RAS guanyl releasing protein 1

The Human Phenotype Ontology links 25 traits to RASGRP1, by body system: features seen in people with one of the gene's rare conditions.

Abnormal cellular phenotype

Trait	How often it is seen
Abnormal T cell proliferation	Always
Decreased circulating IgG concentration	Always
Decreased mitogen-induced T-cell proliferation	Always
Increased circulating IgA concentration	Always
Increased circulating IgG concentration	Always
Increased circulating IgM concentration	Always

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Abnormal CD4:CD8 ratio	Always
Autoimmune hemolytic anemia	Always
B-cell lymphoma	Always
Decreased total CD4+ T cell proportion	Always
Increased CD21low B cell proportion	Always
Autoimmune thrombocytopenia	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged liver and spleen	Always
Increased spleen size	Always
Swollen lymph nodes	Always
Swollen lymph nodes in center of chest	Always
Swollen lymph nodes in the neck	Always

Abnormality of the immune system

Trait	How often it is seen
Antinuclear antibody positivity	Always
Recurrent chest infections	Always
Recurrent infections	Always
Anti-thyroglobulin antibody positivity	Often (30–79%)
Anti-thyroid peroxidase antibody positivity	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Clubbing of fingers	Always

Abnormality of the respiratory system

Trait	How often it is seen
Permanent enlargement of the airways of the lungs	Always

Growth abnormality

Trait	How often it is seen
Faltering weight	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RASGRP1 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test