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Gene

PLCZ1

phospholipase C zeta 1

Summary

Cytogenetic location
12p12.3
Coordinates
Chromosome 12: 18,683,180–18,738,012 (GRCh38)
Exons
15 exons across 54.8 kb
Protein
608 amino acids
Also known as
NYD-SP27, PLCzeta, Czeta
MANE Select transcript
ENST00000266505.12NM_033123.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Male Infertility

    • The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.

      • 1 GenCC submitter rates it definitive or strong

How PLCZ1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where PLCZ1 sits. PLCZ1 and 4 genes near it on chromosome 12, from 18,210,596 to 19,210,595.Chromosome 1212p12.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3318.4 Mb18.6 Mb18.8 Mb19 Mb19.2 MbRERGL: 18,080,869–18,320,107, reverse strandRERGLPIK3C2G: 18,242,947–18,648,416, forward strandPIK3C2GPLCZ1: 18,683,180–18,738,012, reverse strandPLCZ1CAPZA3: 18,738,119–18,742,920, forward strandCAPZA3PLEKHA5: 19,129,513–19,376,403, forward strandPLEKHA5Diagram of PLCZ1: 15 exons on the reverse strand of chromosome 12Exon 6: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 15: 18,683,180–18,683,324, 145 basesExon 14: 18,684,130–18,684,279, 150 basesExon 13: 18,688,089–18,688,218, 130 basesExon 12: 18,694,910–18,695,079, 170 basesExon 11: 18,696,150–18,696,266, 117 basesExon 10: 18,699,794–18,699,950, 157 basesExon 9: 18,701,501–18,701,568, 68 basesExon 8: 18,701,692–18,701,776, 85 basesExon 7: 18,705,166–18,705,315, 150 basesExon 6: 18,712,842–18,712,986, 145 basesExon 5: 18,719,431–18,719,632, 202 basesExon 4: 18,723,311–18,723,542, 232 basesExon 3: 18,736,221–18,736,344, 124 basesExon 2: 18,737,361–18,737,509, 149 basesExon 1: 18,737,932–18,738,012, 81 bases1510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 54.8 kb; 1,827 of those bases code for the protein.

Sequencing PLCZ1

1Low

How hard PLCZ1 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats0.9%
  • GC content11%
  • Reference coverage0%

4

positions in PLCZ1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 54.8 kb of PLCZ1, introns included, not only the 2.1 kb of exons.

Genes linked to the same conditions

Traits linked to PLCZ1

The Human Phenotype Ontology lists these as features of the rare conditions PLCZ1 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). PLCZ1 gene: phospholipase C zeta 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/plcz1

Vancouver

Dante Labs. PLCZ1 gene: phospholipase C zeta 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/plcz1

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