Traits

Traits linked to NPRL2

NPR2 like, GATOR1 complex subunit

The Human Phenotype Ontology links 27 traits to NPRL2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
EEG with focal epileptiform discharges	Very often (80–99%)
Seizure affecting one half of brain	Very often (80–99%)
Focal cortical dysplasia	Often (30–79%)
Grand mal seizures	Often (30–79%)
Interictal EEG abnormality	Often (30–79%)
Nocturnal seizures	Often (30–79%)
Autism spectrum disorder	Sometimes (5–29%)
Behavioral abnormality	Sometimes (5–29%)
Cognitive impairment	Sometimes (5–29%)
Deja vu	Sometimes (5–29%)
Focal aware seizure	Sometimes (5–29%)
Focal impaired awareness seizure	Sometimes (5–29%)
Hallucinations of sound	Sometimes (5–29%)
Infantile spasms	Sometimes (5–29%)
Intellectual disability	Sometimes (5–29%)
Loss of expressive speech	Sometimes (5–29%)
Multifocal epileptiform discharges	Sometimes (5–29%)
Pins and needles feeling	Sometimes (5–29%)
Visual hallucinations	Sometimes (5–29%)
Hemimegalencephaly	Rarely (1–4%)
Hypsarrhythmia	Rarely (1–4%)
More grooves in brain	Rarely (1–4%)
Simple febrile seizure	Rarely (1–4%)
Epilepsy	Not recorded

Abnormality of the integument

Trait	How often it is seen
Flushing	Sometimes (5–29%)
Paleness	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Pain	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NPRL2 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test