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Gene

HSCB

HscB mitochondrial iron-sulfur cluster cochaperone

Summary

Cytogenetic location
22q12.1
Coordinates
Chromosome 22: 28,742,039–28,757,510 (GRCh38)
Exons
6 exons across 15.5 kb
Protein
235 amino acids
Also known as
HSC20, DNAJC20, Jac1
MANE Select transcript
ENST00000216027.8NM_172002.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HSCB yet. The test sequences your whole genome, so your data includes it all the same.

How HSCB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 22, with a bracket where HSCB sits. HSCB and 8 genes near it on chromosome 22, from 28,249,775 to 29,249,774.Chromosome 2222q12.1p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3328.4 Mb28.6 Mb28.8 Mb29 Mb29.2 MbTTC28: 27,978,014–28,679,925, reverse strandTTC28CHEK2: 28,687,738–28,742,422, reverse strandCHEK2HSCB: 28,742,039–28,757,510, forward strandHSCBCCDC117: 28,772,674–28,789,301, forward strandCCDC117XBP1: 28,793,534–28,800,597, reverse strandXBP1ZNRF3: 28,883,537–29,057,488, forward strandZNRF3C22orf31: 29,058,672–29,061,831, reverse strandC22orf31KREMEN1: 29,072,937–29,168,333, forward strandKREMEN1EMID1: 29,205,809–29,259,598, forward strandEMID1Diagram of HSCB: 6 exons on the forward strand of chromosome 22Exon 1: 28,742,039–28,742,331, 293 basesExon 2: 28,743,882–28,743,978, 97 basesExon 3: 28,744,615–28,744,704, 90 basesExon 4: 28,745,864–28,746,008, 145 basesExon 5: 28,751,241–28,751,288, 48 basesExon 6: 28,757,078–28,757,510, 433 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 15.5 kb; 708 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). HSCB gene: HscB mitochondrial iron-sulfur cluster cochaperone. Retrieved 16 October 2026, from https://dantelabs.com/genes/hscb

Vancouver

Dante Labs. HSCB gene: HscB mitochondrial iron-sulfur cluster cochaperone [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hscb

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