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Gene

HSF2BP

heat shock transcription factor 2 binding protein

Summary

Cytogenetic location
21q22.3
Coordinates
Chromosome 21: 43,529,186–43,659,488 (GRCh38)
Exons
9 exons across 130.3 kb
Protein
334 amino acids
Also known as
MEILB2
MANE Select transcript
ENST00000291560.7NM_007031.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • Diminished or absent ability of a female to achieve conception.

      • 1 GenCC submitter rates it definitive or strong

How HSF2BP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 21, with a bracket where HSF2BP sits. HSF2BP and 11 genes near it on chromosome 21, from 43,094,337 to 44,094,336.Chromosome 2121q22.3p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.343.2 Mb43.4 Mb43.6 Mb43.8 Mb44 MbU2AF1: 43,092,956–43,107,605, reverse strandU2AF1CRYAA: 43,169,008–43,172,810, forward strandCRYAASIK1: 43,414,483–43,427,137, reverse strandSIK1HSF2BP: 43,529,186–43,659,488, reverse strandHSF2BPH2BC12L: 43,565,182–43,565,648, forward strandH2BC12LRRP1B: 43,659,542–43,696,080, forward strandRRP1BPDXK: 43,719,061–43,762,307, forward strandPDXKCSTB: 43,772,511–43,776,608, reverse strandCSTBRRP1: 43,789,513–43,821,500, forward strandRRP1AGPAT3: 43,865,081–43,987,592, forward strandAGPAT3: 43,939,919–43,959,673, forward strandTRAPPC10: 44,012,280–44,106,553, forward strandTRAPPC10Diagram of HSF2BP: 9 exons on the reverse strand of chromosome 21Exon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 9: 43,529,186–43,529,962, 777 basesExon 8: 43,592,225–43,592,328, 104 basesExon 7: 43,613,830–43,613,947, 118 basesExon 6: 43,630,322–43,630,454, 133 basesExon 5: 43,633,272–43,633,421, 150 basesExon 4: 43,644,289–43,644,392, 104 basesExon 3: 43,656,587–43,656,737, 151 basesExon 2: 43,658,061–43,658,320, 260 basesExon 1: 43,659,386–43,659,488, 103 bases9515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 130.3 kb; 1,005 of those bases code for the protein.

How a genome test reads HSF2BP

2

positions in HSF2BP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 130.3 kb of HSF2BP, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HSF2BP gene: heat shock transcription factor 2 binding protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/hsf2bp

Vancouver

Dante Labs. HSF2BP gene: heat shock transcription factor 2 binding protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hsf2bp

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