Trait
Progressive brain disease
Clinical name: Progressive encephalopathy
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test12 genes linked to Progressive brain disease
Changes in these genes cause rare conditions in which Progressive brain disease is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Always | In 1 condition |
| GLYCTKglycerate kinase | Very often (80–99%) | In 1 condition |
| TBCEtubulin folding cofactor E | Very often (80–99%) | In 1 condition |
| NADK2NAD kinase 2, mitochondrial | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| WDR45WD repeat domain 45 | Often (30–79%) | In 1 condition |
| THtyrosine hydroxylase | Rarely (1–4%) | In 1 condition |
| TSPOAP1TSPO associated protein 1 | Rarely (1–4%) | In 1 condition |
| HTRA1HtrA serine peptidase 1 | Not recorded | In 1 condition |
| KYNUkynureninase | Not recorded | In 1 condition |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Not recorded | In 1 condition |
| TREX1three prime repair exonuclease 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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