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Trait

Podocyte foot process effacement

An anomaly of podocyte morphology characterized by the loss of the interdigitating foot process pattern (generally called foot process effacement; FPE). The term FPE designates the loss of the usual interdigitating pattern of foot processes of neighboring podocytes, leading to relatively broad expanses of podocyte processes covering the glomerular basement membrane (GBM). It is widely viewed as a pathological derangement that is associated with leakage of macromolecules such as albumin through the glomerular filtration barrier.

HPO HP:0031266

Summary

Also called
Loss of primary podocyte processes
Body system
Abnormality of the genitourinary system

10 genes linked to Podocyte foot process effacement

Changes in these genes cause rare conditions in which Podocyte foot process effacement is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
DAAM2dishevelled associated activator of morphogenesis 2AlwaysIn 1 condition
NOS1APnitric oxide synthase 1 adaptor proteinAlwaysIn 1 condition
ZAP70zeta chain of T cell receptor associated protein kinase 70AlwaysIn 1 condition
KIRREL1kirre like nephrin family adhesion molecule 1Often (30–79%)In 1 condition
YRDCyrdC N6-threonylcarbamoyltransferase domain containingOften (30–79%)In 1 condition
LAMB2laminin subunit beta 2Sometimes (5–29%)In 1 condition
AVILadvillinNot recordedIn 1 condition
DGKEdiacylglycerol kinase epsilonNot recordedIn 1 condition
EMP2epithelial membrane protein 2Not recordedIn 1 condition
SGPL1sphingosine-1-phosphate lyase 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal glomerular visceral epithelial cell morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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