Traits

Traits linked to CDC6

cell division cycle 6

The Human Phenotype Ontology links 62 traits to CDC6, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Decreased size of maxilla	Always
Full lips	Always
Little lower jaw	Always
Long philtrum	Always
Prominent metopic ridge	Always
Submucous cleft hard palate	Always
Triangular face	Always
Absence of lower jaw bones	Very often (80–99%)
Narrow mouth	Very often (80–99%)
Receding chin	Very often (80–99%)
Deformity of the skull	Often (30–79%)
High, narrow palate	Often (30–79%)
Bifid uvula	Sometimes (5–29%)
Cleft palate	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Always
Small earlobe	Always
Small ears	Always
Abnormal shape/structure of ear	Very often (80–99%)
Abnormality of the outer ear	Very often (80–99%)
Absent ear	Very often (80–99%)
Absent ear canal	Very often (80–99%)
Ears rotated toward back of head	Often (30–79%)
Hearing impairment	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Short penis	Always
Undescended testes	Always
Enlarged clitoris	Often (30–79%)
Small clitoris	Often (30–79%)
Small labia majora	Often (30–79%)
Underdeveloped inner lips	Often (30–79%)
Epispadias	Sometimes (5–29%)
Hypospadias	Sometimes (5–29%)
Underdeveloped penis	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Absent kneecap	Always
Elbow dislocation	Always
Irregular thighbone end part	Always
Small innermost thighbone end part	Always
Curvature of little finger	Very often (80–99%)
Permanent flexion of the finger	Often (30–79%)
Curvature of digit	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Delayed bone maturation	Always
Slender long bone	Always
Abnormal shape of end part of bone	Very often (80–99%)
Double-Jointed	Very often (80–99%)
Abnormality of the ribs	Often (30–79%)
Absent collarbone	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Birth length less than 3rd percentile	Always
Faltering weight	Always
Prenatal growth deficiency	Always
Short stature	Always
Growth delay	Very often (80–99%)
Severe short stature	Very often (80–99%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Mild global developmental delay	Always
Intellectual disability	Sometimes (5–29%)
Specific learning disability	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Breathing difficulties	Often (30–79%)
Breathing difficulty	Often (30–79%)
Respiratory failure	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Always
Feeding difficulties	Always

Abnormality of the breast

Trait	How often it is seen
Absent breast	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CDC6 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test