{ "url": "https://dantelabs.com/genes/cdc14a", "gene": { "slug": "cdc14a", "symbol": "CDC14A", "name": "cell division cycle 14A", "hgnc": "HGNC:1718", "summary": null, "location": "1p21.2", "locusType": "gene with protein product", "aliases": [ "Cdc14A1", "Cdc14A2", "cdc14", "DFNB105" ], "previousSymbols": [ "DFNB32" ], "ensemblId": "ENSG00000079335", "entrezId": 8556, "omim": [ "603504" ], "uniprot": [ "Q9UNH5" ], "model": { "build": "GRCh38", "release": "v1.5", "chrom": "1", "start": 100352506, "end": 100520277, "strand": "+", "ensemblTranscript": "ENST00000336454.5", "refseqTranscript": "NM_003672.4", "ensemblProtein": "ENSP00000336739.3", "refseqProtein": "NP_003663.2", "exons": [ { "start": 100352506, "end": 100353003 }, { "start": 100353762, "end": 100353852 }, { "start": 100377546, "end": 100377621 }, { "start": 100390732, "end": 100390824 }, { "start": 100424222, "end": 100424301 }, { "start": 100439932, "end": 100439998 }, { "start": 100442934, "end": 100442996 }, { "start": 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"symbol": "VCAM1", "ensemblId": "ENSG00000162692", "biotype": "protein_coding", "start": 100719684, "end": 100739045, "strand": "+", "slug": "vcam1" }, { "symbol": "EXTL2", "ensemblId": "ENSG00000162694", "biotype": "protein_coding", "start": 100871371, "end": 100896000, "strand": "-", "slug": "extl2" }, { "symbol": "SLC30A7", "ensemblId": "ENSG00000162695", "biotype": "protein_coding", "start": 100896061, "end": 100996627, "strand": "+", "slug": "slc30a7" }, { "symbol": "DPH5", "ensemblId": "ENSG00000117543", "biotype": "protein_coding", "start": 100926286, "end": 101026117, "strand": "-", "slug": "dph5" } ], "truncated": false }, "reports": [ { "slug": "male-infertility", "name": "Male Infertility", "diseases": [ { "mondoId": "MONDO:0100069", "name": "Hearing impairment and infertile male syndrome (CDC14A)", "genes": 1, "inheritance": "autosomal-recessive", "description": "A recessive condition caused by biallelic CDC14A variants that causes hearing loss and, in men, infertility.", "management": null, "evidence": { "gencc": [ "ClinGen" ], "clingen": "Strong", "acmgSf": false, "inheritance": [ "autosomal-recessive" ] }, "sameAsReport": false, "broad": false } ], "url": "https://dantelabs.com/conditions/male-infertility" }, { "slug": "hearing-loss-and-deafness", "name": "Hearing Loss and Deafness", "diseases": [ { "mondoId": "MONDO:0019497", "name": "Nonsyndromic Genetic Hearing Loss", "genes": 97, "inheritance": null, "description": "Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.", "management": "Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.", "evidence": { "gencc": [ "ClinGen", "Labcorp Genetics (formerly Invitae)" ], "clingen": "Definitive", "acmgSf": false, "inheritance": [ "autosomal-recessive" ] }, "sameAsReport": false, "broad": true } ], "url": "https://dantelabs.com/conditions/hearing-loss-and-deafness" } ], "pharmacogenomics": [], "traits": [], "phenotypes": [ { "slug": "abnormal-sperm-morphology", "name": "Abnormal shape of sperm", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/abnormal-sperm-morphology" }, { "slug": "immotile-sperm", "name": "Immotile sperm", "systems": [ "abnormality-of-the-genitourinary-system" ], "url": "https://dantelabs.com/traits/immotile-sperm" }, { "slug": "male-infertility", "name": "Male infertility", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/male-infertility" }, { "slug": "sensorineural-hearing-impairment", "name": "Sensorineural hearing impairment", "systems": [ "abnormality-of-the-ear" ], "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment" } ], "related": [ { "slug": "actg1", "symbol": "ACTG1", "name": "actin gamma 1", "shared": 1, "url": "https://dantelabs.com/genes/actg1" }, { "slug": "afg2b", "symbol": "AFG2B", "name": "AAA ATPase AFG2B", "shared": 1, "url": "https://dantelabs.com/genes/afg2b" }, { "slug": "aifm1", "symbol": "AIFM1", "name": "apoptosis inducing factor mitochondria associated 1", "shared": 1, "url": "https://dantelabs.com/genes/aifm1" }, { "slug": "atp11a", "symbol": "ATP11A", "name": "ATPase phospholipid transporting 11A", "shared": 1, "url": "https://dantelabs.com/genes/atp11a" }, { "slug": "atp2b2", "symbol": "ATP2B2", "name": "ATPase plasma membrane Ca2+ transporting 2", "shared": 1, "url": "https://dantelabs.com/genes/atp2b2" }, { "slug": "cabp2", "symbol": "CABP2", "name": "calcium binding protein 2", "shared": 1, "url": "https://dantelabs.com/genes/cabp2" }, { "slug": "cd164", "symbol": "CD164", "name": "CD164 molecule", "shared": 1, "url": "https://dantelabs.com/genes/cd164" }, { "slug": "cdh23", "symbol": "CDH23", "name": "cadherin related 23", "shared": 1, "url": "https://dantelabs.com/genes/cdh23" }, { "slug": "ceacam16", "symbol": "CEACAM16", "name": "CEA cell adhesion molecule 16, tectorial membrane component", "shared": 1, "url": "https://dantelabs.com/genes/ceacam16" }, { "slug": "cib2", "symbol": "CIB2", "name": "calcium and integrin binding family member 2", "shared": 1, "url": "https://dantelabs.com/genes/cib2" }, { "slug": "cldn14", "symbol": "CLDN14", "name": "claudin 14", "shared": 1, "url": "https://dantelabs.com/genes/cldn14" }, { "slug": "clrn2", "symbol": "CLRN2", "name": "clarin 2", "shared": 1, "url": "https://dantelabs.com/genes/clrn2" } ], "sources": { "bundleId": "2026.10.17-8666dff2", "panel": "2026-10-17", "acmgSf": "SF v3.2" }, "locusKind": "proteinCoding" }, "variants": { "total": 0, "url": null, "items": [] } }