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Gene

A2M

alpha-2-macroglobulin

Summary

Cytogenetic location
12p13.31
Coordinates
Chromosome 12: 9,067,708–9,115,919 (GRCh38)
Exons
36 exons across 48.2 kb
Protein
1,474 amino acids
Also known as
FWP007, S863-7, CPAMD5
MANE Select transcript
ENST00000318602.12NM_000014.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads A2M yet. The test sequences your whole genome, so your data includes it all the same.

How A2M is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 12, with a bracket where A2M sits. A2M and 8 genes near it on chromosome 12, from 8,591,814 to 9,591,813.Chromosome 1212p13.31p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.338.6 Mb8.8 Mb9 Mb9.2 Mb9.4 MbAICDA: 8,602,155–8,613,242, reverse strandAICDAMFAP5: 8,637,346–8,672,519, reverse strandMFAP5RIMKLB: 8,681,483–8,783,095, forward strandRIMKLBA2ML1: 8,822,466–8,887,001, forward strandA2ML1PHC1: 8,913,824–8,944,860, forward strandPHC1M6PR: 8,940,358–8,951,856, reverse strandM6PRKLRG1: 8,950,044–9,165,627, forward strandKLRG1A2M: 9,067,708–9,115,919, reverse strandA2MPZP: 9,148,840–9,208,410, reverse strandPZPDiagram of A2M: 36 exons on the reverse strand of chromosome 12Exon 36: 9,067,708–9,067,839, 132 basesExon 35: 9,068,183–9,068,224, 42 basesExon 34: 9,068,740–9,068,842, 103 basesExon 33: 9,069,745–9,069,813, 69 basesExon 32: 9,070,488–9,070,578, 91 basesExon 31: 9,072,359–9,072,486, 128 basesExon 30: 9,072,653–9,072,871, 219 basesExon 29: 9,074,560–9,074,783, 224 basesExon 28: 9,076,756–9,076,936, 181 basesExon 27: 9,077,346–9,077,420, 75 basesExon 26: 9,077,701–9,077,857, 157 basesExon 25: 9,079,244–9,079,331, 88 basesExon 24: 9,079,639–9,079,815, 177 basesExon 23: 9,080,094–9,080,177, 84 basesExon 22: 9,089,200–9,089,251, 52 basesExon 21: 9,089,902–9,090,023, 122 basesExon 20: 9,090,356–9,090,482, 127 basesExon 19: 9,091,201–9,091,429, 229 basesExon 18: 9,093,465–9,093,579, 115 basesExon 17: 9,094,973–9,095,084, 112 basesExon 16: 9,095,539–9,095,700, 162 basesExon 15: 9,098,607–9,098,756, 150 basesExon 14: 9,099,381–9,099,523, 143 basesExon 13: 9,101,144–9,101,207, 64 basesExon 12: 9,101,447–9,101,674, 228 basesExon 11: 9,104,239–9,104,400, 162 basesExon 10: 9,106,236–9,106,345, 110 basesExon 9: 9,106,491–9,106,605, 115 basesExon 8: 9,107,524–9,107,644, 121 basesExon 7: 9,109,321–9,109,405, 85 basesExon 6: 9,109,867–9,110,035, 169 basesExon 5: 9,110,314–9,110,334, 21 basesExon 4: 9,112,159–9,112,211, 53 basesExon 3: 9,112,377–9,112,536, 160 basesExon 2: 9,113,360–9,113,543, 184 basesExon 1: 9,115,764–9,115,919, 156 bases3630201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 48.2 kb; 4,425 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). A2M gene: alpha-2-macroglobulin. Retrieved 16 October 2026, from https://dantelabs.com/genes/a2m

Vancouver

Dante Labs. A2M gene: alpha-2-macroglobulin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/a2m

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