Trait

Impaired proprioception

A loss or impairment of the sensation of the relative position of parts of the body and joint position.

Also called: Abnormality of proprioception
Body system: Abnormality of the nervous system

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25 genes linked to Impaired proprioception

Changes in these genes cause rare conditions in which Impaired proprioception is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
SETXsenataxin	Always	In 1 condition
TTPAalpha tocopherol transfer protein	Always	In 2 conditions
UCHL1ubiquitin C-terminal hydrolase L1	Always	In 1 condition
FLVCR1FLVCR choline and heme transporter 1	Very often (80–99%)	In 2 conditions
FXNfrataxin	Very often (80–99%)	In 2 conditions
PLEKHG4pleckstrin homology and RhoGEF domain containing G4	Very often (80–99%)	In 1 condition
ATN1atrophin 1	Often (30–79%)	In 1 condition
GBA2glucosylceramidase beta 2	Often (30–79%)	In 1 condition
NEFLneurofilament light chain	Often (30–79%)	In 1 condition
PDYNprodynorphin	Often (30–79%)	In 1 condition
REEP1receptor accessory protein 1	Often (30–79%)	In 1 condition
RTN2reticulon 2	Often (30–79%)	In 1 condition
STUB1STIP1 homology and U-box containing protein 1	Often (30–79%)	In 1 condition
UBAP1ubiquitin associated protein 1	Often (30–79%)	In 1 condition
VPS13Dvacuolar protein sorting 13 homolog D	Often (30–79%)	In 1 condition
VPS41VPS41 subunit of HOPS complex	Often (30–79%)	In 1 condition
ATXN1ataxin 1	Sometimes (5–29%)	In 2 conditions
LMNB1lamin B1	Sometimes (5–29%)	In 1 condition
MTTPmicrosomal triglyceride transfer protein	Sometimes (5–29%)	In 1 condition
PRDM12PR/SET domain 12	Sometimes (5–29%)	In 1 condition
TGM6transglutaminase 6	Sometimes (5–29%)	In 1 condition
VAMP1vesicle associated membrane protein 1	Sometimes (5–29%)	In 1 condition
SAR1Bsecretion associated Ras related GTPase 1B	Rarely (1–4%)	In 1 condition
VPS37AVPS37A subunit of ESCRT-I	Rarely (1–4%)	In 1 condition
ERBB3erb-b2 receptor tyrosine kinase 3	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Somatic sensory dysfunction

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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