{
  "url": "https://dantelabs.com/traits/impaired-proprioception",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "impaired-proprioception",
    "id": "HP:0010831",
    "name": "Impaired proprioception",
    "definition": "A loss or impairment of the sensation of the relative position of parts of the body and joint position.",
    "synonyms": [
      "Abnormality of proprioception"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "somatic-sensory-dysfunction",
        "name": "Somatic sensory dysfunction",
        "url": "https://dantelabs.com/traits/somatic-sensory-dysfunction"
      }
    ],
    "narrower": [
      {
        "slug": "impaired-vibratory-sensation",
        "name": "Impaired vibratory sensation",
        "genes": 64,
        "url": "https://dantelabs.com/traits/impaired-vibratory-sensation"
      },
      {
        "slug": "positive-romberg-sign",
        "name": "Positive Romberg sign",
        "genes": 31,
        "url": "https://dantelabs.com/traits/positive-romberg-sign"
      },
      {
        "slug": "impaired-distal-proprioception",
        "name": "Impaired distal proprioception",
        "genes": 20,
        "url": "https://dantelabs.com/traits/impaired-distal-proprioception"
      },
      {
        "slug": "sensory-ataxia",
        "name": "Sensory ataxia",
        "genes": 17,
        "url": "https://dantelabs.com/traits/sensory-ataxia"
      }
    ],
    "genes": [
      {
        "slug": "setx",
        "symbol": "SETX",
        "hgnc": "HGNC:445",
        "name": "senataxin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setx"
      },
      {
        "slug": "ttpa",
        "symbol": "TTPA",
        "hgnc": "HGNC:12404",
        "name": "alpha tocopherol transfer protein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ttpa"
      },
      {
        "slug": "uchl1",
        "symbol": "UCHL1",
        "hgnc": "HGNC:12513",
        "name": "ubiquitin C-terminal hydrolase L1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uchl1"
      },
      {
        "slug": "flvcr1",
        "symbol": "FLVCR1",
        "hgnc": "HGNC:24682",
        "name": "FLVCR choline and heme transporter 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/flvcr1"
      },
      {
        "slug": "fxn",
        "symbol": "FXN",
        "hgnc": "HGNC:3951",
        "name": "frataxin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fxn"
      },
      {
        "slug": "plekhg4",
        "symbol": "PLEKHG4",
        "hgnc": "HGNC:24501",
        "name": "pleckstrin homology and RhoGEF domain containing G4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plekhg4"
      },
      {
        "slug": "atn1",
        "symbol": "ATN1",
        "hgnc": "HGNC:3033",
        "name": "atrophin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atn1"
      },
      {
        "slug": "gba2",
        "symbol": "GBA2",
        "hgnc": "HGNC:18986",
        "name": "glucosylceramidase beta 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba2"
      },
      {
        "slug": "nefl",
        "symbol": "NEFL",
        "hgnc": "HGNC:7739",
        "name": "neurofilament light chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nefl"
      },
      {
        "slug": "pdyn",
        "symbol": "PDYN",
        "hgnc": "HGNC:8820",
        "name": "prodynorphin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdyn"
      },
      {
        "slug": "reep1",
        "symbol": "REEP1",
        "hgnc": "HGNC:25786",
        "name": "receptor accessory protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/reep1"
      },
      {
        "slug": "rtn2",
        "symbol": "RTN2",
        "hgnc": "HGNC:10468",
        "name": "reticulon 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtn2"
      },
      {
        "slug": "stub1",
        "symbol": "STUB1",
        "hgnc": "HGNC:11427",
        "name": "STIP1 homology and U-box containing protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stub1"
      },
      {
        "slug": "ubap1",
        "symbol": "UBAP1",
        "hgnc": "HGNC:12461",
        "name": "ubiquitin associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubap1"
      },
      {
        "slug": "vps13d",
        "symbol": "VPS13D",
        "hgnc": "HGNC:23595",
        "name": "vacuolar protein sorting 13 homolog D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13d"
      },
      {
        "slug": "vps41",
        "symbol": "VPS41",
        "hgnc": "HGNC:12713",
        "name": "VPS41 subunit of HOPS complex",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps41"
      },
      {
        "slug": "atxn1",
        "symbol": "ATXN1",
        "hgnc": "HGNC:10548",
        "name": "ataxin 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atxn1"
      },
      {
        "slug": "lmnb1",
        "symbol": "LMNB1",
        "hgnc": "HGNC:6637",
        "name": "lamin B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb1"
      },
      {
        "slug": "mttp",
        "symbol": "MTTP",
        "hgnc": "HGNC:7467",
        "name": "microsomal triglyceride transfer protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mttp"
      },
      {
        "slug": "prdm12",
        "symbol": "PRDM12",
        "hgnc": "HGNC:13997",
        "name": "PR/SET domain 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdm12"
      },
      {
        "slug": "tgm6",
        "symbol": "TGM6",
        "hgnc": "HGNC:16255",
        "name": "transglutaminase 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgm6"
      },
      {
        "slug": "vamp1",
        "symbol": "VAMP1",
        "hgnc": "HGNC:12642",
        "name": "vesicle associated membrane protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vamp1"
      },
      {
        "slug": "sar1b",
        "symbol": "SAR1B",
        "hgnc": "HGNC:10535",
        "name": "secretion associated Ras related GTPase 1B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sar1b"
      },
      {
        "slug": "vps37a",
        "symbol": "VPS37A",
        "hgnc": "HGNC:24928",
        "name": "VPS37A subunit of ESCRT-I",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps37a"
      },
      {
        "slug": "erbb3",
        "symbol": "ERBB3",
        "hgnc": "HGNC:3431",
        "name": "erb-b2 receptor tyrosine kinase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb3"
      }
    ]
  }
}