Traits

Traits linked to KLRC4

killer cell lectin like receptor C4

The Human Phenotype Ontology links 85 traits to KLRC4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Kaip dažnai pasireiškia
Migraine	Labai dažnai (80–99%)
Abnormal gait	Dažnai (30–79%)
Confusion	Dažnai (30–79%)
Headache	Dažnai (30–79%)
Weakness of one side of body	Dažnai (30–79%)
Abnormal pyramidal sign	Kartais (5–29%)
Ataxia	Kartais (5–29%)
Behavioral abnormality	Kartais (5–29%)
Cranial nerve paralysis	Kartais (5–29%)
Epilepsy	Kartais (5–29%)
Increased reflexes	Kartais (5–29%)
Irritability	Kartais (5–29%)
Loss of developmental milestones	Kartais (5–29%)
Memory impairment	Kartais (5–29%)
Pins and needles feeling	Kartais (5–29%)
Rise in pressure inside skull	Kartais (5–29%)

Abnormality of the cardiovascular system

Trait	Kaip dažnai pasireiškia
Inflammation of blood vessel	Labai dažnai (80–99%)
Abnormal myocardium morphology	Kartais (5–29%)
Aortic regurgitation	Kartais (5–29%)
Blood clot in artery of lung	Kartais (5–29%)
Disruption of blood oxygen supply to brain	Kartais (5–29%)
Endocarditis	Kartais (5–29%)
Heart attack	Kartais (5–29%)
Increased spleen size	Kartais (5–29%)
Inflammation of heart muscle	Kartais (5–29%)
Mitral regurgitation	Kartais (5–29%)
Swelling or irritation of membrane around heart	Kartais (5–29%)
Swollen lymph nodes	Kartais (5–29%)

Abnormality of the immune system

Trait	Kaip dažnai pasireiškia
Meningitis	Labai dažnai (80–99%)
Acne	Dažnai (30–79%)
Erythema nodosum	Dažnai (30–79%)
Immunologic hypersensitivity	Dažnai (30–79%)
Increased inflammatory response	Dažnai (30–79%)
Pimple	Dažnai (30–79%)
Brain inflammation	Kartais (5–29%)
Muscle inflammation	Kartais (5–29%)
Non-infectious meningitis	Kartais (5–29%)

Abnormality of the eye

Trait	Kaip dažnai pasireiškia
Extreme sensitivity of the eyes to light	Labai dažnai (80–99%)
Nongranulomatous uveitis	Dažnai (30–79%)
Panuveitis	Dažnai (30–79%)
Blindness	Kartais (5–29%)
Clouding of the lens of the eye	Kartais (5–29%)
Noninflammatory retina disease	Kartais (5–29%)
Optic neuritis	Kartais (5–29%)
Retrobulbar optic neuritis	Kartais (5–29%)

Abnormality of the digestive system

Trait	Kaip dažnai pasireiškia
Nausea and vomiting	Labai dažnai (80–99%)
Abdominal pain	Dažnai (30–79%)
Anorexia	Kartais (5–29%)
Malabsorption	Kartais (5–29%)
Pancreatic inflammation	Kartais (5–29%)
Diarrhea	Retai (1–4 %)

Abnormality of the genitourinary system

Trait	Kaip dažnai pasireiškia
Inflammation of testicles	Labai dažnai (80–99%)
Genital ulcers	Dažnai (30–79%)
Epididymitis	Kartais (5–29%)
Glomerulopathy	Kartais (5–29%)
Renal failure	Kartais (5–29%)
Glomerulonephritis	Retai (1–4 %)

Laboratory abnormality

Trait	Kaip dažnai pasireiškia
Fever	Labai dažnai (80–99%)
Elevated circulating C-reactive protein concentration	Dažnai (30–79%)
High ESR	Dažnai (30–79%)
AA amyloidosis	Kartais (5–29%)
Episodic fever	Kartais (5–29%)
Fluid around lungs	Kartais (5–29%)

Abnormality of blood and blood-forming tissues

Trait	Kaip dažnai pasireiškia
Blood clot in vein	Dažnai (30–79%)
Gastrointestinal bleeding	Dažnai (30–79%)
Superficial thrombophlebitis	Dažnai (30–79%)
Blood clot in artery	Kartais (5–29%)

Abnormality of the integument

Trait	Kaip dažnai pasireiškia
Firm lump under the skin	Labai dažnai (80–99%)
Papule	Labai dažnai (80–99%)
Abnormal blistering of the skin	Dažnai (30–79%)
Positive pathergy test	Dažnai (30–79%)

Constitutional symptom

Trait	Kaip dažnai pasireiškia
Fatigue	Labai dažnai (80–99%)
Muscle ache	Labai dažnai (80–99%)
Joint pain	Dažnai (30–79%)
Death of body tissue due to lack of blood flow or infection	Kartais (5–29%)

Abnormality of head or neck

Trait	Kaip dažnai pasireiškia
Mouth sore	Labai dažnai (80–99%)
Recurrent canker sores	Labai dažnai (80–99%)
Dry eye syndrome	Kartais (5–29%)

Abnormality of the respiratory system

Trait	Kaip dažnai pasireiškia
Coughing up blood	Kartais (5–29%)
Inflammation of tissues lining lungs and chest	Kartais (5–29%)
Lung infiltrates	Kartais (5–29%)

Abnormality of the musculoskeletal system

Trait	Kaip dažnai pasireiškia
Arthritis	Labai dažnai (80–99%)
Death of bone due to decreased blood supply	Kartais (5–29%)

Abnormality of the ear

Trait	Kaip dažnai pasireiškia
Dizziness	Kartais (5–29%)

Growth abnormality

Trait	Kaip dažnai pasireiškia
Weight loss	Kartais (5–29%)

Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.

Iš kur tai žinoma

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KLRC4 and how often each is seen. Find out more at hpo.jax.org.

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