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Gene

WDR72

WD repeat domain 72

Summary

Cytogenetic location
15q21.3
Coordinates
Chromosome 15: 53,513,741–53,759,663 (GRCh38)
Exons
20 exons across 245.9 kb
Protein
1,102 amino acids
Inheritance
Autosomal dominant
Also known as
FLJ38736
MANE Select transcript
ENST00000360509.10NM_182758.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Amelogenesis Imperfecta

    • Autosomal dominant
      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How WDR72 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where WDR72 sits. WDR72 and 1 gene near it on chromosome 15, from 53,136,702 to 54,136,701.Chromosome 1515q21.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.353.2 Mb53.4 Mb53.6 Mb53.8 Mb54 MbWDR72: 53,513,741–53,759,663, reverse strandWDR72UNC13C: 53,978,201–54,631,744, forward strandUNC13CDiagram of WDR72: 20 exons on the reverse strand of chromosome 15Exon 17: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 15: 10 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 4 known disease-causing sitesExon 20: 53,513,741–53,517,754, 4,014 basesExon 19: 53,523,218–53,523,322, 105 basesExon 18: 53,597,079–53,597,274, 196 basesExon 17: 53,609,513–53,609,592, 80 basesExon 16: 53,613,666–53,613,757, 92 basesExon 15: 53,615,426–53,616,243, 818 basesExon 14: 53,665,572–53,665,768, 197 basesExon 13: 53,699,750–53,699,945, 196 basesExon 12: 53,702,134–53,702,354, 221 basesExon 11: 53,704,988–53,705,233, 246 basesExon 10: 53,705,927–53,706,074, 148 basesExon 9: 53,710,857–53,710,953, 97 basesExon 8: 53,711,336–53,711,481, 146 basesExon 7: 53,712,772–53,712,891, 120 basesExon 6: 53,714,434–53,714,510, 77 basesExon 5: 53,715,193–53,715,367, 175 basesExon 4: 53,716,607–53,716,685, 79 basesExon 3: 53,722,802–53,722,908, 107 basesExon 2: 53,732,997–53,733,161, 165 basesExon 1: 53,759,633–53,759,663, 31 bases201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.3 kb of the gene's 245.9 kb; 3,309 of those bases code for the protein.

How a genome test reads WDR72

37

positions in WDR72 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 245.9 kb of WDR72, introns included, not only the 7.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WDR72 gene: WD repeat domain 72. Retrieved 16 October 2026, from https://dantelabs.com/genes/wdr72

Vancouver

Dante Labs. WDR72 gene: WD repeat domain 72 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/wdr72

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