Traits

Traits linked to WDR37

WD repeat domain 37

The Human Phenotype Ontology links 27 traits to WDR37, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Downturned corners of mouth	Always
Prominent nasal bridge	Always
Smooth philtrum	Always
High forehead	Very often (80–99%)
Development of small head that was not present at birth	Often (30–79%)
Eye folds	Often (30–79%)
Redundant neck skin	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
An opening in the wall separating the top two chambers of the heart	Often (30–79%)
Hole in heart wall separating two lower heart chambers	Often (30–79%)
Patent ductus arteriosus	Often (30–79%)
Enlarged heart	Sometimes (5–29%)
Patent foramen ovale	Sometimes (5–29%)
Tricuspid regurgitation	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Absent speech development	Always
Epilepsy	Always
Global developmental delay	Always
Intellectual disability	Always
Abnormality of the cerebellum	Not recorded

Abnormality of the eye

Trait	How often it is seen
Notched pupil	Very often (80–99%)
Abnormally small eyeball	Often (30–79%)
Wide-set eyes	Often (30–79%)
Peters anomaly	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Often (30–79%)
Sensorineural hearing impairment	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Abnormality of the palm lines	Always

Abnormality of the breast

Trait	How often it is seen
Wide-spaced nipples	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Bilateral cryptorchidism	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WDR37 and how often each is seen. Find out more at hpo.jax.org.

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