Traits

Traits linked to SUGCT

succinyl-CoA:glutarate-CoA transferase

The Human Phenotype Ontology links 19 traits to SUGCT, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormal cerebral white matter morphology	Sometimes (5–29%)
Abnormal periventricular white matter morphology	Sometimes (5–29%)
Global developmental delay	Sometimes (5–29%)
Impulsivity	Sometimes (5–29%)
Lethargy	Sometimes (5–29%)
Specific learning disability	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Glutaric aciduria	Always
Abnormal circulating enzyme concentration	Very often (80–99%)
Elevated circulating glutaric acid concentration	Sometimes (5–29%)
Ketoacidosis	Sometimes (5–29%)
Ketonuria	Sometimes (5–29%)
Reduced peroxisomal glutaryl-CoA oxidase activity	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Diarrhea	Not recorded
Vomiting	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Enlarged thyroid gland in neck	Sometimes (5–29%)
Overactive thyroid	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Not recorded

Abnormality of the integument

Trait	How often it is seen
Spinal dimple	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SUGCT and how often each is seen. Find out more at hpo.jax.org.

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