Traits

Traits linked to STAT6

signal transducer and activator of transcription 6

The Human Phenotype Ontology links 44 traits to STAT6, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Gastrointestinal eosinophilia	Often (30–79%)
Acid reflux	Sometimes (5–29%)
Abnormal peritoneum morphology	Rarely (1–4%)
Constipation	Rarely (1–4%)
Liver cancer	Rarely (1–4%)
Pelvic mass	Rarely (1–4%)
Eosinophilic infiltration of the esophagus	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Baby eczema	Very often (80–99%)
Food allergy	Very often (80–99%)
Anaphylaxis	Often (30–79%)
Asthma	Often (30–79%)
Recurrent respiratory infections	Often (30–79%)
Recurrent skin infections	Often (30–79%)
Recurrent viral infections	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Genital tumor	Sometimes (5–29%)
Abnormality of the prostate	Rarely (1–4%)
Prostate cancer	Rarely (1–4%)
Urinary retention	Rarely (1–4%)
Uterine cancer	Rarely (1–4%)
Vaginal tumor	Rarely (1–4%)

Laboratory abnormality

Trait	How often it is seen
Decreased circulating C-peptide concentration	Rarely (1–4%)
Fever	Rarely (1–4%)
Low blood sugar	Rarely (1–4%)
Recurrent low blood sugar levels	Rarely (1–4%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Osteoporosis	Sometimes (5–29%)
Hypophosphatemic rickets	Rarely (1–4%)
Lumbago	Rarely (1–4%)

Abnormal tissue mass

Trait	How often it is seen
Abnormal tissue mass	Sometimes (5–29%)
Soft tissue neoplasm	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
High blood eosinophil count	Very often (80–99%)
B-cell lymphoma	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Loss of consciousness	Rarely (1–4%)
Nervous system cancer	Rarely (1–4%)

Abnormality of the respiratory system

Trait	How often it is seen
Neoplasia of the pleura	Sometimes (5–29%)
Lung cancer	Rarely (1–4%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Sometimes (5–29%)
Night sweats	Rarely (1–4%)

Growth abnormality

Trait	How often it is seen
Short stature	Often (30–79%)
Weight loss	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Increased circulating IgE concentration	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Abnormality of the forehead	Rarely (1–4%)

Abnormality of the endocrine system

Trait	How often it is seen
Hypoinsulinemia	Rarely (1–4%)

Abnormality of the eye

Trait	How often it is seen
Double vision	Rarely (1–4%)

Abnormality of the thoracic cavity

Trait	How often it is seen
Abnormal mediastinum morphology	Rarely (1–4%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to STAT6 and how often each is seen. Find out more at hpo.jax.org.

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