Traits

Traits linked to PIGF

phosphatidylinositol glycan anchor biosynthesis class F

The Human Phenotype Ontology links 26 traits to PIGF, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Often (30–79%)
Coarse facial features	Often (30–79%)
Decreased size of tooth	Often (30–79%)
Delayed eruption of permanent teeth	Often (30–79%)
Little lower jaw	Often (30–79%)
Narrow mouth	Often (30–79%)
Nasal tip, upturned	Often (30–79%)
Open mouth	Often (30–79%)
Short nose	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Small thumbnail	Always
Underdeveloped fifth fingernail	Always
Underdeveloped toenails	Always
Absent fifth toenail	Often (30–79%)
Small fingernail	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Intellectual disability, severe	Always
Absent speech development	Often (30–79%)
Grand mal seizures	Often (30–79%)
Head-banging	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Bilateral triphalangeal thumbs	Often (30–79%)
Short outermost bone of toe	Often (30–79%)
Short outermost finger bone	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
An opening in the wall separating the top two chambers of the heart	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Early onset of puberty	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Poor head control	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Impaired toileting ability	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PIGF and how often each is seen. Find out more at hpo.jax.org.

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