Traits

Traits linked to PDYN

prodynorphin

The Human Phenotype Ontology links 20 traits to PDYN, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Degeneration of cerebellum	Always
Limb ataxia	Always
Inability to coordinate movements when walking	Very often (80–99%)
Increased reflexes	Very often (80–99%)
Progressive cerebellar ataxia	Very often (80–99%)
Babinski sign	Often (30–79%)
Difficulty articulating speech	Often (30–79%)
Impaired distal proprioception	Often (30–79%)
Impaired distal vibration sensation	Often (30–79%)
Impaired proprioception	Often (30–79%)
Impaired vibration sensation in the lower limbs	Often (30–79%)
Lack of coordination of movement	Often (30–79%)
Tremor	Often (30–79%)
Agenesis of corpus callosum	Sometimes (5–29%)
Peripheral nerve disease	Sometimes (5–29%)
CNS demyelination	Not recorded
Loss of brain cells	Not recorded
Nerve damage causing decreased feeling and movement	Not recorded

Abnormality of the eye

Trait	How often it is seen
Slow eye movements	Often (30–79%)
Uncoordinated eye movement	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PDYN and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test