Traits

Traits linked to NUDCD3

NudC domain containing 3

The Human Phenotype Ontology links 28 traits to NUDCD3, by body system: features seen in people with one of the gene's rare conditions.

NUDCD3

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Abnormal lymphocyte morphology	Very often (80–99%)
Elevated white blood count	Often (30–79%)
High blood eosinophil count	Often (30–79%)
Cancer of lymphatic system	Sometimes (5–29%)
Low number of red blood cells or hemoglobin	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Red scaly skin caused by inflammatory skin disease	Very often (80–99%)
Severe combined immunodeficiency	Very often (80–99%)
Pneumonia	Often (30–79%)
Autoimmunity	Sometimes (5–29%)
Infection in blood stream	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Hair loss	Very often (80–99%)
Dry skin	Often (30–79%)
Itching	Often (30–79%)
Thickened skin	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Abnormality of the wide portion of a long bone	Sometimes (5–29%)
Short toe	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Swollen lymph nodes	Very often (80–99%)
Increased spleen size	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Chronic diarrhea	Very often (80–99%)
Enlarged liver	Very often (80–99%)

Abnormality of the endocrine system

Trait	How often it is seen
Thyroid gland inflammation	Sometimes (5–29%)
Underactive thyroid	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Fever	Often (30–79%)
Fluid retention	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Sparse or absent eyebrows	Often (30–79%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Desquamation of skin soon after birth	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Nephrotic syndrome	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NUDCD3 and how often each is seen. Find out more at hpo.jax.org.

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