Skip to content
Use your HSA or FSA funds

Gene

NKX2-2

NK2 homeobox 2

Summary

Cytogenetic location
20p11.22
Coordinates
Chromosome 20: 21,511,017–21,514,064 (GRCh38)
Exons
2 exons across 3 kb
Protein
273 amino acids
Also known as
NKX2.2
Previous symbols
NKX2B
MANE Select transcript
ENST00000377142.5NM_002509.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Diabetes Mellitus

    • A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems

  • Neonatal Diabetes Mellitus

    • Diabetes diagnosed in the first months of life, either permanent or transient, caused by single-gene defects in insulin production or secretion.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Most people with KCNJ11 or ABCC8 neonatal diabetes can switch from insulin injections to sulfonylurea tablets, often with better glucose control.

How NKX2-2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 20, with a bracket where NKX2-2 sits. NKX2-2 and 4 genes near it on chromosome 20, from 21,012,541 to 22,012,540.Chromosome 2020p11.22p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3321.2 Mb21.4 Mb21.6 Mb21.8 Mb22 MbKIZ: 21,125,975–21,273,506, forward strandKIZXRN2: 21,303,281–21,390,251, forward strandXRN2NKX2-4: 21,395,152–21,397,526, reverse strandNKX2-4NKX2-2: 21,511,017–21,514,064, reverse strandNKX2-2PAX1: 21,705,659–21,718,481, forward strandPAX1Diagram of NKX2-2: 2 exons on the reverse strand of chromosome 20Exon 2: 21,511,017–21,512,485, 1,469 basesExon 1: 21,513,411–21,514,064, 654 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 3 kb; 822 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NKX2-2 gene: NK2 homeobox 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/nkx2-2

Vancouver

Dante Labs. NKX2-2 gene: NK2 homeobox 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nkx2-2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test