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Gene

MYL9

myosin light chain 9

Summary

Cytogenetic location
20q11.23
Coordinates
Chromosome 20: 36,541,519–36,551,447 (GRCh38)
Exons
4 exons across 9.9 kb
Protein
172 amino acids
Also known as
MYRL2, MLC2, LC20, MRLC1
MANE Select transcript
ENST00000279022.7NM_006097.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Visceral Myopathy, CIPO & MMIHS

    • Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS)

      A severe newborn condition with a greatly enlarged bladder, a small colon and poor bowel movement, caused by variants in smooth-muscle genes such as ACTG2, MYH11, MYLK, MYL9 and LMOD1.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Early diagnosis supports planning for nutritional support, bladder drainage and, in some cases, transplant.

How MYL9 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 20, with a bracket where MYL9 sits. MYL9 and 13 genes near it on chromosome 20, from 36,046,483 to 37,046,482.Chromosome 2020q11.23p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3336.2 Mb36.4 Mb36.6 Mb36.8 Mb37 MbEPB41L1: 36,091,504–36,232,799, forward strandEPB41L1AAR2: 36,236,131–36,270,918, forward strandAAR2DLGAP4: 36,306,302–36,528,637, forward strandDLGAP4MYL9: 36,541,519–36,551,447, forward strandMYL9TGIF2: 36,571,894–36,593,950, forward strandTGIF2TGIF2-RAB5IF: 36,574,553–36,612,384, forward strandTGIF2-RAB5IFRAB5IF: 36,605,718–36,612,557, forward strandRAB5IFSLA2: 36,612,318–36,646,219, reverse strandSLA2NDRG3: 36,651,766–36,746,157, reverse strandNDRG3DSN1: 36,751,791–36,774,298, reverse strandDSN1MTCL2: 36,777,447–36,863,795, reverse strandMTCL2TLDC2: 36,873,061–36,898,931, forward strandTLDC2SAMHD1: 36,890,216–36,951,893, reverse strandSAMHD1RBL1: 36,996,088–37,096,034, reverse strandRBL1Diagram of MYL9: 4 exons on the forward strand of chromosome 20Exon 1: 36,541,519–36,541,561, 43 basesExon 2: 36,544,859–36,545,068, 210 basesExon 3: 36,548,032–36,548,193, 162 basesExon 4: 36,549,077–36,551,447, 2,371 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 9.9 kb; 519 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MYL9 gene: myosin light chain 9. Retrieved 17 October 2026, from https://dantelabs.com/genes/myl9

Vancouver

Dante Labs. MYL9 gene: myosin light chain 9 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/myl9

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