Traits

Traits linked to LMOD2

leiomodin 2

The Human Phenotype Ontology links 28 traits to LMOD2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Aortic regurgitation	Always
Complete right bundle branch block	Always
Elevated heart rate	Always
Left atrial enlargement	Always
Mitral regurgitation	Always
Monomorphic ventricular tachycardia	Always
Myofiber disarray	Always
Paroxysmal ventricular tachycardia	Always
Severely reduced left ventricular ejection fraction	Always
Stretched and thinned heart muscle	Always
Left ventricular systolic dysfunction	Very often (80–99%)
Abnormal heart rate	Often (30–79%)
Cardiac failure	Often (30–79%)
Cardiogenic shock	Often (30–79%)
Multifocal atrial tachycardia	Often (30–79%)
Tricuspid regurgitation	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Increased Z-disc width	Often (30–79%)
EMG abnormality	Sometimes (5–29%)
Loss of fat tissue in localized area	Sometimes (5–29%)
Muscle tissue disease	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Bleeding in brain	Always
Thromboembolic stroke	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Exertional breathlessness	Often (30–79%)
Orthopnea	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Myocardial sarcomeric disarray	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Fluid retention	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LMOD2 and how often each is seen. Find out more at hpo.jax.org.

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