Trait
Impaired executive functioning
A disturbance of executive functioning, which is broadly defined as the set of abilities that allow for the planning, executing, monitoring, and self-correcting of goal-directed behavior while inhibiting task-irrelevant behavior. At least some degree of executive skill is needed to complete most cognitive tasks, and deficits in executive abilities are central to many clinical conditions, including fronto-temporal dementia.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test16 genes linked to Impaired executive functioning
Changes in these genes cause rare conditions in which Impaired executive functioning is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CSF1Rcolony stimulating factor 1 receptor | Always | In 1 condition |
| CTSAcathepsin A | Always | In 1 condition |
| FASTKD5FASTK mitochondrial RNA regulator 5 | Always | In 1 condition |
| LAMB1laminin subunit beta 1 | Always | In 1 condition |
| RAB3ARAB3A, member RAS oncogene family | Always | In 1 condition |
| RRP12ribosomal RNA processing 12 homolog | Always | In 1 condition |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Always | In 1 condition |
| APTXaprataxin | Often (30–79%) | In 1 condition |
| CYLDCYLD lysine 63 deubiquitinase | Often (30–79%) | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Often (30–79%) | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Often (30–79%) | In 1 condition |
| FAR1fatty acyl-CoA reductase 1 | Sometimes (5–29%) | In 1 condition |
| MMACHCmetabolism of cobalamin associated C | Sometimes (5–29%) | In 1 condition |
| NPTX1neuronal pentraxin 1 | Sometimes (5–29%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Sometimes (5–29%) | In 1 condition |
| VPS13Dvacuolar protein sorting 13 homolog D | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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