Traits

Traits linked to HNRNPC

heterogeneous nuclear ribonucleoprotein C

The Human Phenotype Ontology links 31 traits to HNRNPC, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed motor skills	Always
Delayed speech and language development	Always
Difficulty sleeping	Always
Global developmental delay	Always
Intellectual disability, mild	Always
Intellectual disability, severe	Always
IQ between 34 and 49	Always
Delayed fine motor development	Very often (80–99%)
Delayed ability to walk	Often (30–79%)
Happy demeanor	Often (30–79%)
Poor concentration	Often (30–79%)
Absent speech development	Sometimes (5–29%)
Delayed CNS myelination	Sometimes (5–29%)
Grand mal seizures	Sometimes (5–29%)
Motor tics	Sometimes (5–29%)
Obstructive sleep apnea	Sometimes (5–29%)
Typical absence seizure	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Smooth philtrum	Often (30–79%)
Thin red part of the upper lip	Often (30–79%)
Abnormally small head	Sometimes (5–29%)
Broad head shape	Sometimes (5–29%)
Downward slanting of the opening between the eyelids	Sometimes (5–29%)
Prominent nose	Sometimes (5–29%)
Round face	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Deeply set eye	Often (30–79%)
Abnormally close eyes	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Often (30–79%)
Spasticity and rigidity of muscles	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to HNRNPC and how often each is seen. Find out more at hpo.jax.org.

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