Traits

Traits linked to GYS2

glycogen synthase 2

The Human Phenotype Ontology links 17 traits to GYS2, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Glucose in urine	Often (30–79%)
High levels of ketone bodies	Often (30–79%)
Ketonuria	Often (30–79%)
Ketotic hypoglycemia	Often (30–79%)
Postprandial hyperglycemia	Often (30–79%)
Elevated lipids in blood	Sometimes (5–29%)
High liver enzymes	Sometimes (5–29%)
Higher than normal levels of lactate in blood	Not recorded
Low blood sugar in newborn	Not recorded
Low blood sugar when fasting	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Irritability	Often (30–79%)
Epilepsy	Sometimes (5–29%)
Global developmental delay	Sometimes (5–29%)
Lethargy	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Sometimes (5–29%)
Short stature	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Abnormality of the gastrointestinal tract	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GYS2 and how often each is seen. Find out more at hpo.jax.org.

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