Traits

Traits linked to CYC1

cytochrome c1

The Human Phenotype Ontology links 21 traits to CYC1, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Dehydration	Always
Elevated lactate:pyruvate ratio	Always
Episodic ketoacidosis	Always
High blood ammonia levels	Always
High blood sugar	Always
High liver enzymes	Always
Higher than normal levels of lactate in blood	Always
Increased lactate in body	Always
Ketoacidosis	Always
Ketonuria	Always
Low blood sugar	Often (30–79%)
Metabolic ketoacidosis	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Coma	Often (30–79%)
Encephalopathy	Often (30–79%)
Worsening neurological symptoms	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Vomiting	Always
Acute liver failure	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)
Growth delay	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Decreased activity of mitochondrial complex III	Always

Abnormality of the eye

Trait	How often it is seen
Drooping upper eyelid	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CYC1 and how often each is seen. Find out more at hpo.jax.org.

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