Traits

Traits linked to CD46

CD46 molecule

The Human Phenotype Ontology links 37 traits to CD46, by body system: features seen in people with one of the gene's rare conditions.

CD46

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low platelet count	Always
Microangiopathic hemolytic anemia	Always
Hemolytic anemia	Very often (80–99%)
Hypofibrinogenemia	Often (30–79%)
Prolonged prothrombin time	Often (30–79%)
Decreased mean corpuscular hemoglobin concentration	Sometimes (5–29%)
Disseminated intravascular coagulation	Sometimes (5–29%)
Bleeding in brain	Rarely (1–4%)
Internal bleeding	Rarely (1–4%)
Low number of red blood cells or hemoglobin	Not recorded

Laboratory abnormality

Trait	How often it is seen
High liver enzymes	Always
Generalized edema	Often (30–79%)
High urine protein levels	Often (30–79%)
Excess fluid in lungs	Sometimes (5–29%)
Fluid around lungs	Sometimes (5–29%)
Hemoglobin in urine	Sometimes (5–29%)
Increased circulating lactate dehydrogenase concentration	Sometimes (5–29%)
Blood in urine	Not recorded
Elevated creatinine	Not recorded
Increased blood urea nitrogen	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Sometimes (5–29%)
Nausea	Sometimes (5–29%)
Vomiting	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Acute kidney injury	Always
Hemolytic-uremic syndrome	Always
Absent urine output	Not recorded

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)
Epigastric pain	Sometimes (5–29%)
Shoulder pain	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)
Low blood pressure	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Placental abruption	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Decreased circulating complement C3 concentration	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Poor wound healing	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Back pain	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Headache	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Increased body weight	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CD46 and how often each is seen. Find out more at hpo.jax.org.

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