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Gene

GLIS2

GLIS family zinc finger 2

Summary

Cytogenetic location
16p13.3
Coordinates
Chromosome 16: 4,316,067–4,339,595 (GRCh38)
Exons
7 exons across 23.5 kb
Protein
524 amino acids
Inheritance
Autosomal recessive
Also known as
NPHP7
MANE Select transcript
ENST00000433375.2NM_032575.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephronophthisis and Senior-Løken Syndrome

    • NephronophthisisAutosomal recessive

      A recessively inherited kidney disease, caused by variants in NPHP1 and other cilia genes, in which progressive tubulointerstitial scarring leads to kidney failure, typically in the first three decades of life.

      • ClinGen rates the link moderate
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing allows regular kidney function monitoring, timely planning for dialysis or transplantation, and carrier testing for relatives.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How GLIS2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 16, with a bracket where GLIS2 sits. GLIS2 and 23 genes near it on chromosome 16, from 3,827,831 to 4,827,830.Chromosome 1616p13.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.34 Mb4.2 Mb4.4 Mb4.6 Mb4.8 MbCREBBP: 3,725,054–3,880,734, reverse strandCREBBPADCY9: 3,953,387–4,116,493, reverse strandADCY9SRL: 4,189,369–4,242,283, reverse strandSRLTFAP4: 4,257,186–4,273,075, reverse strandTFAP4GLIS2: 4,316,067–4,339,595, forward strandGLIS2PAM16: 4,330,378–4,355,607, reverse strandPAM16CORO7-PAM16: 4,340,251–4,420,494, reverse strandCORO7-PAM16CORO7: 4,354,542–4,425,705, reverse strandCORO7VASN: 4,371,841–4,383,538, forward strandVASNDNAJA3: 4,425,805–4,460,593, forward strandDNAJA3NMRAL1: 4,461,673–4,495,763, reverse strandNMRAL1HMOX2: 4,474,246–4,510,663, forward strandHMOX2CDIP1: 4,510,619–4,538,833, reverse strandCDIP1C16orf96: 4,556,336–4,600,772, forward strandC16orf96UBALD1: 4,608,879–4,615,046, reverse strandUBALD1MGRN1: 4,616,493–4,690,977, forward strandMGRN1NUDT16L1: 4,693,562–4,695,861, forward strandNUDT16L1ANKS3: 4,696,500–4,734,388, reverse strandANKS3DNAAF8: 4,734,315–4,749,396, forward strandDNAAF8ZNF500: 4,748,239–4,767,624, reverse strandZNF500SEPTIN12: 4,777,606–4,788,398, reverse strandSEPTIN12SMIM22: 4,788,376–4,796,731, forward strandSMIM22ROGDI: 4,796,962–4,802,926, reverse strandROGDIGLYR1: 4,803,202–4,847,343, reverse strandGLYR1Diagram of GLIS2: 7 exons on the forward strand of chromosome 16Exon 1: 4,316,067–4,316,254, 188 basesExon 2: 4,332,215–4,332,452, 238 basesExon 3: 4,333,347–4,333,519, 173 basesExon 4: 4,334,801–4,334,977, 177 basesExon 5: 4,335,060–4,335,193, 134 basesExon 6: 4,335,275–4,335,393, 119 basesExon 7: 4,336,725–4,339,595, 2,871 bases124675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 23.5 kb; 1,575 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GLIS2 gene: GLIS family zinc finger 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/glis2

Vancouver

Dante Labs. GLIS2 gene: GLIS family zinc finger 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/glis2

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