Trait
Severe infection
A type of infection that is regarded as a sign of a pathological susceptibility to infection because of unusual severity or intensity of the infection.
Summary
- Also called
- Unusual course of infection
- Body system
- Abnormality of the immune system
Reference genomeGRCh38hg38
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Get my Genome Test15 genes linked to Severe infection
Changes in these genes cause rare conditions in which Severe infection is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| COPZ1coat protein complex I subunit zeta 1 | Always | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Always | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Very often (80–99%) | In 1 condition |
| CXCR2C-X-C motif chemokine receptor 2 | Often (30–79%) | In 1 condition |
| FCGR3BFc gamma receptor IIIb | Often (30–79%) | In 1 condition |
| FOXN1forkhead box N1 | Often (30–79%) | In 1 condition |
| FOXP3forkhead box P3 | Often (30–79%) | In 1 condition |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Often (30–79%) | In 1 condition |
| IGKCimmunoglobulin kappa constant | Often (30–79%) | In 1 condition |
| BCL11ABCL11 transcription factor A | Sometimes (5–29%) | In 1 condition |
| HBBhemoglobin subunit beta | Sometimes (5–29%) | In 1 condition |
| HBG1hemoglobin subunit gamma 1 | Sometimes (5–29%) | In 1 condition |
| HBG2hemoglobin subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| KLF1KLF transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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