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Gene

SIX2

SIX homeobox 2

Summary

Cytogenetic location
2p21
Coordinates
Chromosome 2: 45,005,182–45,009,452 (GRCh38)
Exons
2 exons across 4.3 kb
Protein
291 amino acids
MANE Select transcript
ENST00000303077.7NM_016932.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SIX2 yet. The test sequences your whole genome, so your data includes it all the same.

How SIX2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 2, with a bracket where SIX2 sits. SIX2 and 3 genes near it on chromosome 2, from 44,507,317 to 45,507,316.Chromosome 22p21p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.344.6 Mb44.8 Mb45 Mb45.2 Mb45.4 MbCAMKMT: 44,361,874–44,776,433, forward strandCAMKMTSIX3: 44,941,696–44,946,071, forward strandSIX3SIX2: 45,005,182–45,009,452, reverse strandSIX2SRBD1: 45,384,544–45,612,165, reverse strandSRBD1Diagram of SIX2: 2 exons on the reverse strand of chromosome 2Exon 2: 45,005,182–45,006,485, 1,304 basesExon 1: 45,008,551–45,009,452, 902 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 4.3 kb; 876 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). SIX2 gene: SIX homeobox 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/six2

Vancouver

Dante Labs. SIX2 gene: SIX homeobox 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/six2

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