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Gene

CDK8

cyclin dependent kinase 8

Summary

Cytogenetic location
13q12.13
Coordinates
Chromosome 13: 26,254,129–26,405,238 (GRCh38)
Exons
13 exons across 151.1 kb
Protein
464 amino acids
Also known as
K35
MANE Select transcript
ENST00000381527.8NM_001260.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CDK8 yet. The test sequences your whole genome, so your data includes it all the same.

How CDK8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 13, with a bracket where CDK8 sits. CDK8 and 5 genes near it on chromosome 13, from 25,829,684 to 26,829,683.Chromosome 1313q12.13p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3426 Mb26.2 Mb26.4 Mb26.6 Mb26.8 MbATP8A2: 25,371,897–26,025,851, forward strandATP8A2SHISA2: 26,044,497–26,052,023, reverse strandSHISA2RNF6: 26,132,112–26,222,549, reverse strandRNF6CDK8: 26,254,129–26,405,238, forward strandCDK8WASF3: 26,557,650–26,688,948, forward strandWASF3GPR12: 26,755,200–26,761,028, reverse strandGPR12Diagram of CDK8: 13 exons on the forward strand of chromosome 13Exon 1: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 4 known disease-causing sitesExon 1: 26,254,129–26,254,769, 641 basesExon 2: 26,337,567–26,337,642, 76 basesExon 3: 26,349,072–26,349,182, 111 basesExon 4: 26,353,740–26,353,880, 141 basesExon 5: 26,382,814–26,382,871, 58 basesExon 6: 26,385,211–26,385,342, 132 basesExon 7: 26,393,367–26,393,510, 144 basesExon 8: 26,396,285–26,396,354, 70 basesExon 9: 26,397,153–26,397,225, 73 basesExon 10: 26,400,453–26,400,550, 98 basesExon 11: 26,401,269–26,401,347, 79 basesExon 12: 26,401,466–26,401,624, 159 basesExon 13: 26,403,956–26,405,238, 1,283 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.1 kb of the gene's 151.1 kb; 1,395 of those bases code for the protein.

How a genome test reads CDK8

8

positions in CDK8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 151.1 kb of CDK8, introns included, not only the 3.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CDK8 gene: cyclin dependent kinase 8. Retrieved 16 October 2026, from https://dantelabs.com/genes/cdk8

Vancouver

Dante Labs. CDK8 gene: cyclin dependent kinase 8 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cdk8

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