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Gene

TUBB8

tubulin beta 8 class VIII

Summary

Cytogenetic location
10p15.3
Coordinates
Chromosome 10: 46,888–49,296 (GRCh38)
Exons
4 exons across 2.4 kb
Protein
444 amino acids
Also known as
bA631M21.2
MANE Select transcript
ENST00000568584.6NM_177987.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • inherited oocyte maturation defect
      • 3 GenCC submitters rate it definitive or strong

How TUBB8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where TUBB8 sits. TUBB8 and 2 genes near it on chromosome 10, from 1 to 548,091.Chromosome 1010p15.3p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.30.1 Mb0.2 Mb0.3 Mb0.4 Mb0.5 MbTUBB8: 46,888–49,296, reverse strandTUBB8ZMYND11: 130,088–254,771, forward strandZMYND11DIP2C: 274,201–689,937, reverse strandDIP2CDiagram of TUBB8: 4 exons on the reverse strand of chromosome 10Exon 4: 15 known disease-causing sitesExon 3: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 4: 46,888–48,114, 1,227 basesExon 3: 48,615–48,725, 111 basesExon 2: 48,804–48,912, 109 basesExon 1: 49,182–49,296, 115 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 2.4 kb; 1,335 of those bases code for the protein.

How a genome test reads TUBB8

17

positions in TUBB8 where ClinVar classes a change as pathogenic or likely pathogenic

17 of them (100%) fall in regions short reads find hard.

  • Low mappability (15 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (17 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 2.4 kb of TUBB8, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TUBB8 gene: tubulin beta 8 class VIII. Retrieved 17 October 2026, from https://dantelabs.com/genes/tubb8

Vancouver

Dante Labs. TUBB8 gene: tubulin beta 8 class VIII [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tubb8

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