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Gene

RORB

RAR related orphan receptor B

Summary

Cytogenetic location
9q21.13
Coordinates
Chromosome 9: 74,497,335–74,693,177 (GRCh38)
Exons
10 exons across 195.8 kb
Protein
459 amino acids
Also known as
RZRB, NR1F2, ROR-BETA, RORβ, RZR-BETA
MANE Select transcript
ENST00000376896.8NM_006914.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RORB yet. The test sequences your whole genome, so your data includes it all the same.

How RORB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where RORB sits. RORB and 5 genes near it on chromosome 9, from 74,095,256 to 75,095,255.Chromosome 99q21.13p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.374.2 Mb74.4 Mb74.6 Mb74.8 Mb75 MbRORB: 74,497,335–74,693,177, forward strandRORBTRPM6: 74,722,495–74,888,094, reverse strandTRPM6C9orf40: 74,945,947–74,952,921, reverse strandC9orf40CARNMT1: 74,980,790–75,028,480, reverse strandCARNMT1NMRK1: 75,060,570–75,088,831, reverse strandNMRK1OSTF1: 75,088,421–75,149,989, forward strandOSTF1Diagram of RORB: 10 exons on the forward strand of chromosome 9Exon 3: 3 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 9: 3 known disease-causing sitesExon 1: 74,497,335–74,497,983, 649 basesExon 2: 74,630,282–74,630,367, 86 basesExon 3: 74,634,631–74,634,772, 142 basesExon 4: 74,642,414–74,642,815, 402 basesExon 5: 74,660,617–74,660,738, 122 basesExon 6: 74,662,474–74,662,606, 133 basesExon 7: 74,665,488–74,665,595, 108 basesExon 8: 74,667,791–74,667,901, 111 basesExon 9: 74,671,789–74,671,901, 113 basesExon 10: 74,685,463–74,693,177, 7,715 bases12468105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.6 kb of the gene's 195.8 kb; 1,380 of those bases code for the protein.

How a genome test reads RORB

15

positions in RORB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 195.8 kb of RORB, introns included, not only the 9.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RORB gene: RAR related orphan receptor B. Retrieved 17 October 2026, from https://dantelabs.com/genes/rorb

Vancouver

Dante Labs. RORB gene: RAR related orphan receptor B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rorb

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