Traits

Traits linked to TNFAIP3

TNF alpha induced protein 3

The Human Phenotype Ontology links 52 traits to TNFAIP3, by body system: features seen in people with one of the gene's rare conditions.

TNFAIP3

Abnormality of the immune system

Trait	How often it is seen
Antinuclear antibody positivity	Very often (80–99%)
Anti-complement component C1q antibody positivity	Often (30–79%)
Anti-ribosome Po antibody positivity	Often (30–79%)
Anti-titin antibody positivity	Often (30–79%)
Antineutrophil antibody positivity	Often (30–79%)
Decreased circulating complement C3 concentration	Often (30–79%)
Decreased circulating complement C4 concentration	Often (30–79%)
Malar rash	Often (30–79%)
Skin rash	Often (30–79%)
Anti-dsDNA antibody positivity	Sometimes (5–29%)
Anti-La/SS-B antibody positivity	Sometimes (5–29%)
Anti-nucleoporin 62 antibody positivity	Sometimes (5–29%)
Anti-phosphatidic acid antibody positivity	Sometimes (5–29%)
Anti-Ro52/TRIM21 antibody positivity	Sometimes (5–29%)
Anti-Sm antibody positivity	Sometimes (5–29%)
Anti-U1 ribonucleoprotein antibody positivity	Sometimes (5–29%)
Discoid lupus rash	Sometimes (5–29%)
Lupus anticoagulant	Sometimes (5–29%)
Serositis	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Fever	Very often (80–99%)
High urine protein levels	Very often (80–99%)
Blood in urine	Often (30–79%)
High urine neutrophil count	Often (30–79%)
Episodic fever	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased blood leukocyte number	Often (30–79%)
Decreased blood lymphocyte number	Sometimes (5–29%)
Hemolytic anemia	Sometimes (5–29%)
Low platelet count	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Mouth sore	Always
Abnormal color of the oral mucosa	Sometimes (5–29%)
Abnormality of salivation	Sometimes (5–29%)
Inflammation of the lips	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)
Raynaud phenomenon	Often (30–79%)
Swollen lymph nodes	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Anorexia	Very often (80–99%)
Colitis	Sometimes (5–29%)
Ileal ulcer	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Chorea	Sometimes (5–29%)
Depression	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Anterior uveitis	Sometimes (5–29%)
Noninflammatory retina disease	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Genital ulcers	Very often (80–99%)
Lupus nephritis	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Hair loss	Often (30–79%)
Photosensitive skin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Often (30–79%)
Polyarticular arthritis	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)
Malaise	Very often (80–99%)

Growth abnormality

Trait	How often it is seen
Weight loss	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TNFAIP3 and how often each is seen. Find out more at hpo.jax.org.

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