Traits

Traits linked to TLR7

toll like receptor 7

The Human Phenotype Ontology links 58 traits to TLR7, by body system: features seen in people with one of the gene's rare conditions.

TLR7

Abnormality of the immune system

Trait	How often it is seen
Antinuclear antibody positivity	Always
Severe SARS-CoV-2 infection	Always
Severe viral infection	Always
Anti-aquaporin 4 antibody positivity	Often (30–79%)
Anti-complement component C1q antibody positivity	Often (30–79%)
Anti-ribosome Po antibody positivity	Often (30–79%)
Anti-titin antibody positivity	Often (30–79%)
Antineutrophil antibody positivity	Often (30–79%)
Decreased circulating complement C3 concentration	Often (30–79%)
Decreased circulating complement C4 concentration	Often (30–79%)
Inflammation of spinal cord	Often (30–79%)
Malar rash	Often (30–79%)
Systemic lupus erythematosus	Often (30–79%)
Anti-dsDNA antibody positivity	Sometimes (5–29%)
Anti-La/SS-B antibody positivity	Sometimes (5–29%)
Anti-nucleoporin 62 antibody positivity	Sometimes (5–29%)
Anti-phosphatidic acid antibody positivity	Sometimes (5–29%)
Anti-Ro52/TRIM21 antibody positivity	Sometimes (5–29%)
Anti-Sm antibody positivity	Sometimes (5–29%)
Anti-U1 ribonucleoprotein antibody positivity	Sometimes (5–29%)
Discoid lupus rash	Sometimes (5–29%)
Serositis	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Autoimmune thrombocytopenia	Often (30–79%)
Decreased blood leukocyte number	Often (30–79%)
Decreased blood lymphocyte number	Often (30–79%)
Low platelet count	Often (30–79%)
Hemolytic anemia	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)
Hypertensive crisis	Often (30–79%)
Mitral regurgitation	Often (30–79%)
Raynaud phenomenon	Often (30–79%)
Swollen lymph nodes	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Anxiety	Often (30–79%)
Chorea	Often (30–79%)
Headache	Often (30–79%)
Depression	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Fever	Very often (80–99%)
High urine protein levels	Very often (80–99%)
Blood in urine	Often (30–79%)
Episodic fever	Often (30–79%)
High urine neutrophil count	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Mouth sore	Often (30–79%)
Abnormal color of the oral mucosa	Sometimes (5–29%)
Abnormality of salivation	Sometimes (5–29%)
Inflammation of the lips	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)
Malaise	Very often (80–99%)
Joint pain	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Optic neuritis	Often (30–79%)
Noninflammatory retina disease	Rarely (1–4%)

Abnormality of the integument

Trait	How often it is seen
Hair loss	Often (30–79%)
Photosensitive skin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Often (30–79%)
Polyarticular arthritis	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Anorexia	Very often (80–99%)

Abnormality of the genitourinary system

Trait	How often it is seen
Lupus nephritis	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Weight loss	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TLR7 and how often each is seen. Find out more at hpo.jax.org.

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